Results 101 to 110 of about 353,849 (343)
A Genetic Predisposition to Hypertension? [PDF]
Hypertension, 2004 Hypertension is a majorpublic health problem, and yet, the molecular mechanisms underlying hypertension are poorly understood in the majority of patients. A complex disorder, both environmental and genetic factors predispose individuals to hypertension.
openaire +2 more sources
CLINICAL APPLICABILITY OF PROPOSED ALGORITHM FOR IDENTIFYING INDIVIDUALS AT RISK FOR HEREDITARY HEMATOLOGIC MALIGNANCIES [PDF]
, 2017 Over the past decade, more than 12 genes have been identified to cause hereditary predispositions to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML),
Clifford, Maggie
core +1 more source
Advanced Science, EarlyView.The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino +20 more
wiley +1 more source
Detection of Rs9939609 Polymorphism of Fto Gene and Rs324011 Polymorphism of Stat6 Gene and Severity Degree of Bronchial Asthma Associated with Obesity [PDF]
, 2017 The aim of this research was to analyze the distribution of FTO and STAT6 genes polymorphism in patients with bronchial asthma (BA), associated with obesity (Ob) depending on the main disease severity degree.Materials and methods.
Fediv, A. (Alexander) +1 more
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Advanced Science, EarlyView.This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao +10 more
wiley +1 more source
Genetic predisposition of cholesterol gallstone disease
Annals of Hepatology, 2006 Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems.
Alejandro Hernández-Nazará +4 more
doaj
Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction
Advanced Science, EarlyView.A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod +9 more
wiley +1 more source
Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma
Frontiers in OncologyIntroductionMedulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents.
Li Shun Mak +10 more
doaj +1 more source
Genetic and phenotypic markers for successful athletic performance forecast
Pedagogy and Psychology of Sport, 2018 In the modern research and practical provisions for the children’s and adolescent sports, due emphasis will be made on a timely detection of the physical activity limiting factors and prudent initiatives to remove or mitigate these factors with the ...
Vitalii Marinich
doaj +1 more source
Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. [PDF]
, 2017 PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing.
Adams, Sophie B +8 more
core +1 more source