Results 121 to 130 of about 353,849 (343)
ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
Case Reports in Dermatology, 2013 Lichen sclerosus et atrophicus is a skin disease of multifactorial etiology which appears in patients with genetic or hormonal predisposition and autoimmune disease.
Georgeta Doulaveri +4 more
doaj +1 more source
Possible evidence for genetic predisposition to nondisjunction in man. [PDF]
, 1988 Talaat I. Farag, A. S. Teebi
openalex +1 more source
Phosphorus Vacancy‐Induced Built‐In Electric Field for Electromagnetic Properties Modulation
Advanced Science, EarlyView.The advantages of defect‐induced polarization resulting from group VA anion vacancies, particularly phosphorus vacancies (VP) are analyzed in comparison to the anion vacancies of other elements. P atoms possess both plentiful high‐energy unpaired valence electrons in 3p orbitals and moderate nonmetallicity, thus the selection of VP for regulating EM ...
Yu Zhang +8 more
wiley +1 more source
The awareness of the citizens of Swietokrzyskie Voivodeship on the genetic predisposition on cancer
Journal of Education, Health and Sport, 2017 Introduction: Cancers are the major concern of the modern world, they are in fact the fourth most common cause of death in the world and second in developed countries. The root cause of tumour development lies in genetics.
Izabela Kamila Wojarska
doaj +1 more source
Attitudes Toward Updated Genetic Testing Among Patients with Unexplained Mismatch Repair Deficiency [PDF]
, 2018 Individuals who have colorectal cancer (CRC) or endometrial cancer (EC) displaying loss of immunohistochemical (IHC) staining of one or more mismatch repair (MMR) proteins without a causative germline mutation are said to have unexplained mismatch repair
Omark, Jessica
core +1 more source
Advanced Science, EarlyView.Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu +9 more
wiley +1 more source
Genetics and Economic Mobility [PDF]
, 2008 Presents a literature review on the link between genetic traits, such as cognitive skills, health, mental health, personality, and appearance, and academic and economic success.
Jessica Kronstadt
core
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source