Results 131 to 140 of about 364,926 (322)

Genetic Testing for Breast Cancer Predisposition in 1999: Which Molecular Strategy and which Family Criteria? [PDF]

, 1999
Dominique Stoppa‐Lyonnet, Maria A. Caligo, Diana Eccles, D. Gareth Evans, N. E. Haites, N. S. Hodgson, Pål Møller, P. Morrison, C. M. Steel, Hans F. A. Vasen, Jenny C. Chang   +10 more
openalex   +1 more source

Dupuytren\u27s Disease [PDF]

, 2017
Dupuytren\u27s disease (DD) is a chronic condition in which fibrosis of tissue beneath the palm of the hand occurs. Causes and mechanisms of this disease\u27s development are still not entirely understood.
Pinckney, Leah C.
core   +1 more source

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

Advanced Science, EarlyView.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong, Zhen Guo, Yu‐Lan Ma, Ming‐Yu Wang, Hai‐Yang Ni, Pan Wang, Wen‐Jun Qiu, En‐Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi‐Zhu Tang   +11 more
wiley   +1 more source

GENETIC FOUNDATIONS OF THE BRONCHIAL ASTHMA

Педиатрическая фармакология, 2008
The article overviews the results of the studies of the genetic foundations of predisposition to the bronchial asthma. The authors provide detailed information on the molecular and genetic mechanisms of the bronchial asthma, roles performed by the ...
A.Yu. Asanov, L.S. Namazova, V.G. Pinelis, N.V. Zhurkova, N.I. Voznesenskaya   +4 more
doaj   +2 more sources

Diagnostic criteria, specific mutations, and genetic predisposition in gastrointestinal stromal tumors

The Application of Clinical Genetics, 2010
Jean-Baptiste Bachet1,2, Jean-François Emile1,31EA4340 “Epidémiologie et oncogènes des tumeurs digestives”, Faculté de médecine PIFO, UVSQ, Guyancourt, France; 2Service de ...
Jean-Baptiste Bachet, Jean-François Emile   +1 more
doaj  

Polymorphisms in angiotensin converting enzyme gene and reflux nephropathy: a genetic predisposition to scar formation? [PDF]

, 1997
Seza Özen, Mehmet Alikaşifoĝlu, E Tunçbilek, Ayşı̇n Bakkaloğlu, Nesrin Beşbaş, B. Aran, U Saatçi   +6 more
openalex   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

High incidence and prevalence of multiple sclerosis in south east Scotland: evidence of a genetic predisposition [PDF]

, 1998
Peter M. Rothwell, D. G. Charlton
openalex   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Effects of lifestyle, personality, symptoms of anxiety and depression, and genetic predisposition on subjective sleep disturbance and sleep pattern [PDF]

, 1998
Andrew C. Heath, Lindon J. Eaves, Katherine M. Kirk, Nicholas G. Martin   +3 more
openalex   +1 more source