Results 141 to 150 of about 372,458 (325)
Genetic Predisposition to Hematologic Malignancies
Cold Spring Harbor Perspectives in MedicineHematologic malignancies (HMs) have been increasingly recognized in association with an underlying genetic predisposition syndrome (GPS) in individuals of all ages. It is critical for hematology and oncology providers to be aware of the diagnostic findings, physical examination findings, and aspects of family history that raise suspicion for an ...
Kayla V. Hamilton +2 more
openaire +2 more sources
The Application of Clinical Genetics, 2010 Jean-Baptiste Bachet1,2, Jean-François Emile1,31EA4340 “Epidémiologie et oncogènes des tumeurs digestives”, Faculté de médecine PIFO, UVSQ, Guyancourt, France; 2Service de ...
Jean-Baptiste Bachet +1 more
doaj
CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover
Advanced Science, EarlyView.This study identifies CIDEC, an lipid droplet (LD)‐fusion associated protein upregulated by CREBH during early regeneration, as a negative regulator of liver regeneration through its unexpected role in sequestering triglyceride (TG) within LDs. CIDEC depletion reduces LD size, mobilizes LD‐stored TG, enhances TG catabolism and free fatty acid (FFA ...
Feng Ouyang +16 more
wiley +1 more source
An investigation of the progression from Barrett's esophagus to adenocarcinoma [PDF]
, 2016 Barrett's esophagus is a metaplasia of the epithelium of the lower esophagus from a normal squamous appearance to a columnar appearance more typically found in the stomach. It is normally caused by prolonged gastric reflux. While Barrett's esophagus is
Palmese, Scott Joseph
core +1 more source
Advanced Science, EarlyView.The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan +9 more
wiley +1 more source
Genetic Basis of Familial Lymphoma Predisposition [PDF]
, 2013 Lymphomas are classified into Hodgkin and non-Hodgkin lymphomas (HL and NHL), and they are further categorized into tens of different subtypes. This thesis has focused on two rare lymphoma subtypes: nodular lymphocyte predominant Hodgkin lymphoma (NLPHL)
Saarinen, Silva
core
Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease [PDF]
, 2014 Paulo José Basso +6 more
openalex +1 more source
The effect of genetic predisposition to Alzheimer’s disease and related traits on recruitment bias in a study of cognitive ageing [PDF]
, 2023 Lina Gómez +10 more
openalex +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source