Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk [PDF]
, 2015 The risk of developing type 2 diabetes mellitus (T2DM) is determined by a complex interplay involving lifestyle factors and genetic predisposition. Despite this, many studies do not consider the relative contributions of this complex array of factors to ...
Celia G. Walker +8 more
openalex +4 more sources
Unique Features of Germline Variation in Five Egyptian Familial Breast Cancer Families Revealed by Exome Sequencing. [PDF]
PLoS ONE, 2017 Genetic predisposition increases the risk of familial breast cancer. Recent studies indicate that genetic predisposition for familial breast cancer can be ethnic-specific.
Yeong C Kim +10 more
doaj +1 more source
Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. [PDF]
PLoS ONE, 2011 BACKGROUND: Development of Type 2 diabetes, like obesity, is promoted by a genetic predisposition. Although several genetic variants have been identified they only account for a small proportion of risk.
Peter Arner +3 more
doaj +1 more source
Genetic predisposition to cancer [PDF]
Clinical Medicine, 2005 Over recent decades a number of genes causing predisposition to cancer have been identified. Some of these cause rare autosomal dominant monogenic cancer predisposition syndromes. In the majority of families, the increased incidence of cancers is due to a multifactorial aetiology with a number of lower penetrance cancer predisposition genes interacting
Clare, Turnbull, Shirley, Hodgson
openaire +2 more sources
Lessons From Pediatric MDS: Approaches to Germline Predisposition to Hematologic Malignancies
Frontiers in Oncology, 2022 Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline predisposition to hematologic malignancies, referred to as germline predisposition herein.
Serine Avagyan, Akiko Shimamura
doaj +1 more source
Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]
, 2020 Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D. +7 more
core +2 more sources
Modifier genes and Lynch syndrome: some considerations
Hereditary Cancer in Clinical Practice, 2022 Lynch Syndrome (LS) is a highly variable entity with some patients presenting at very young ages with malignancy whereas others may never develop a malignancy yet carry an unequivocal genetic predisposition to disease.
Rodney J. Scott
doaj +1 more source
Genetic predisposition for cervical cancer
Акушерство, гинекология и репродукция, 2020 Aim: to assess a role of genetic factors and human papillomavirus (HPV) in developing cervical neoplasia based on analyzing current publications on virus-induced carcinogenesis.Materials and methods.
T. V. Rotaru +2 more
doaj +1 more source
Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]
, 2018 BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara +6 more
core +2 more sources
Androgenetic alopecia: a review [PDF]
, 2017 Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism
Caro, Gemma +7 more
core +1 more source