Results 191 to 200 of about 372,458 (325)

Variants in the ATM‐CHEK2‐BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma

, 2014
Anna Wójcicka, Małgorzata Czetwertyńska, Michał Świerniak, Joanna Długosińska, Monika Maciąg, Agnieszka Czajka, Kinga Dymecka, Anna Kubiak, Adam Kot, Rafał Ploski, Albert de la Chapelle, Krystian Jażdżewski   +11 more
openalex   +1 more source

Supplementary Table 8 from Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer

, 2023
Xiaoyan Wang, Ruiyi Tian, Xiaoyu Zong, Myung Sik Jeon, Jingqin Luo, Graham A. Colditz, Jean S. Wang, Konstantinos K. Tsilidis, Yo‐El S. Ju, Ramaswamy Govindan, Varun Puri, Yin Cao   +11 more
openalex   +1 more source

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

Advanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen, Qingwei Zeng, Tangchang Xu, Xinyue Qi, Kaiyi Li, Jing Wei, Liang Hao   +6 more
wiley   +1 more source

Molecular mechanisms and genetic predisposition to osteoarthritis and osteosarcoma through Mendelian inheritance patterns. [PDF]

Discov Oncol
Fei H, Huang W, Chen Y, Yang S.
europepmc   +1 more source

Supplementary Figure 1 from Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer

Xiaoyan Wang, Ruiyi Tian, Xiaoyu Zong, Myung Sik Jeon, Jingqin Luo, Graham A. Colditz, Jean S. Wang, Konstantinos K. Tsilidis, Yo‐El S. Ju, Ramaswamy Govindan, Varun Puri, Yin Cao   +11 more
openalex   +1 more source

The genetic predisposition

, 2000
RésuméLa prédisposition génétique est un risque endogène, d’origine génétique, de contracter une maladie ou de la transmettre à ses enfants, risque dont la réalisation incertaine est soumise à des facteurs catalyseurs exogènes. Depuis 1994, des conditions ont été posées par le législateur à la détection de prédisposition génétique.
openaire   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, EarlyView.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Association of Physical Frailty and Genetic Predisposition with Risk of Irreversible Eye Diseases. [PDF]

Ophthalmol Sci
Xu Z, Lin R, Wang X, Liu Y, Huang C, Wang C, Bao Z.   +6 more
europepmc   +1 more source

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

Advanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning, Munir H. Buhaya, Victor V. Nguyen, Afeefah Khazi‐Syed, Haider A. Ali, Adil Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, Victor D. Varner, Cheryl M. Lewis, Emina H. Huang, Jacopo Ferruzzi   +18 more
wiley   +1 more source

Genetic predisposition to osteosarcoma

BoneKEy Reports, 2013
openaire   +3 more sources