Results 251 to 260 of about 364,926 (322)

Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort

Angewandte Chemie, EarlyView.
Validating biomarkers of disease is necessary for clinical use. The Health Surveillance Panel (83 peptides from 57 proteins) was developed as a PRM assay and evaluated using the Stellar‐MS platform. The assay was validated with a large clinical cohort of inflammatory bowel disease patients alongside quality controls.
Qin Fu, Philip M. Remes, Jihyeon Lee, Cristina Jacob, Dalin Li, Manasa Vegesna, Koen Raedschelders, Ali Haghani, Emebet Mengesha, Philip Debbas, Esthelle Hoedt, Sandy Joung, Susan Cheng, Scott Peterman, Justyna Fert‐Bober, Gil Y. Melmed, Dermot P.B. McGovern, Christopher I. Murray, Jennifer E. Van Eyk   +18 more
wiley   +2 more sources

Genetic predisposition to thyrotoxicosis and onset of knee osteoarthritis. [PDF]

Front Endocrinol (Lausanne)
He Z, Gong Z, Jiao S, Xiong W, Hao X, Cui J, Zhang J.   +6 more
europepmc   +1 more source

Depression Polygenicity and Disease Activity and Disability Worsening in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective A better understanding of factors associated with multiple sclerosis (MS) disease activity and disability is needed. Given the strong link between comorbid depression and MS disease activity and disability, we aimed to determine whether the depression genetic burden, as modelled using its polygenic score, is associated with MS disease ...
Ali Manouchehrinia, Kathryn C. Fitzgerald, Amber Salter, Ruth Ann Marrie, Lars Alfredsson, Charles N. Bernstein, James M. Bolton, Gary Cutter, John D. Fisk, Lesley A. Graff, Carol A. Hitchon, Jan Hillert, Ingrid Kockum, Yi Lu, Fred D. Lublin, Kyla McKay, Tomas Olsson, Scott Patten, Amit Patki, Hayley Riel, Klementy Shchetynsky, Pernilla Stridh, Hemant K. Tiwari, Jerry S. Wolinsky, Kaarina Kowalec   +24 more
wiley   +1 more source

Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes

Angewandte Chemie, EarlyView.
The final step in insulin exocytosis from pancreatic beta cells is the formation of the fusion pore. We combined single‐cell amperometry with microsensors and fluorescence microscopy to monitor insulin exocytosis from different perspectives. Our results reveal a link between impaired fusion pore function and diminished insulin secretion, highlighting ...
Amir Hatami, Nikhil R. Gandasi, Haiqiang Dou, Lakshmi Kothegala, Lena Eliasson, Andrew Ewing, Patrik Rorsman   +6 more
wiley   +2 more sources

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk. [PDF]

Circ Genom Precis Med
Gajendragadkar PR, Von Ende A, Murgia F, Offer A, Camm CF, Wijesurendra RS, Casadei B, Hopewell JC.   +7 more
europepmc   +1 more source

Genetic predisposition to cardiovascular disease potentiates delayed doxorubicin cardiotoxicity during pregnancy

, 2006
Pamela Fettig, Anthony H. Tobias, Lois Jane Heller, Fred S. Apple, Leslie C. Sharkey   +4 more
openalex   +1 more source

Cutting‐Edge Advancements in Physical Stimulation for Spiral Ganglion Neuron Protection and Regeneration

Advanced NanoBiomed Research, EarlyView.
Physical stimulation strategies have emerged as a therapeutic avenue for the regeneration of spiral ganglion neurons. This review explores diverse physical stimulation modalities—including topographical modulation, electrical stimulation, and photostimulation—each operating through distinct mechanisms to regulate SGN biological behavior. By elucidating
Yuhan Bai, Bin Zhang, Hong Cheng, Yunzhu Huang, Xinyue Han, Yangnan Hu, Renjie Chai, Wei Cao   +7 more
wiley   +1 more source

Genetic predisposition to childhood cancer.

World J Clin Pediatr
Roganovic J.
europepmc   +1 more source