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Genetic Testing for Cancer Predisposition
Annual Review of Medicine, 2001▪ Abstract Clinical cancer genetics is becoming an integral part of the care of cancer patients. This review describes the clinical aspects, genetics, and clinical genetic management of most of the major hereditary cancer susceptibility syndromes. Multiple endocrine neoplasia type 2, von Hippel-Lindau disease, and familial adenomatous polyposis are ...
C, Eng, H, Hampel, A, de la Chapelle
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Genetic Testing for Cancer Predisposition
Cancer Nursing, 2002The onslaught of genetic innovations in the past decade has resulted in the ongoing identification of a spectrum of genes, some of which, when mutated, result in cancer susceptibility. The impact of these discoveries on healthcare provides an opportunity to enhance health promotion and long-term health outcomes by identifying at-risk individuals before
Kathleen A, Calzone +1 more
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Genetic predisposition in pancreatitis
Current Opinion in Pediatrics, 2018Purpose of review Genetic mutations are the primary cause for acute recurrent (ARP) and chronic pancreatitis in children. Further, our medical approach for many diseases is changing from a one-drug therapy to more individualized therapeutic strategies.
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Genetic Predisposition, Humans
2014The translation from genetic knowledge to a molecular understanding of disease is contributing to the development of improved diagnostic and therapeutic products. Here, we examine the progress in molecular understanding of autoimmune disease that has been facilitated by genetic approaches, from candidate gene studies to genetic linkage and, more ...
Jordan, Margaret A. +3 more
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Genetic Predisposition to Gallbladder Stones
Seminars in Liver Disease, 2007Geographic and ethnic differences in gallstone prevalence rates and familial clustering of cholelithiasis imply that genetic factors influence the risk of gallstone formation. Recently, twin, family, and linkage studies confirmed a genetic predisposition to the development of symptomatic gallstones. In rare instances, mutations in single genes confer a
Henning, Wittenburg, Frank, Lammert
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Genetic Predisposition to West Syndrome
Epilepsia, 1993Summary:To determine the recurrence risk of West syndrome (WS), we studied the familial antecedents of consecutively referred patients. Among siblings, there was an increased incidence of WS but not of febrile convulsions. Familial incidence of epilepsy was intermediate between the epileptic and nonepileptic control groups.
O, Dulac +5 more
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Genetic predisposition to breast cancer
Cancer, 1992Breast cancer is the most common cancer among American women. Because metastatic breast cancer is an incurable disease, efforts to decrease breast cancer mortality have focused on early detection and improved treatment. Identification and analysis of a specific genetic susceptibility could permit detection of susceptible women and greatly increase the ...
M H, Skolnick, L A, Cannon-Albright
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Genetic predisposition to skin cancer
Current Opinion in Oncology, 1999Here we review recent insights in the genetics of skin cancer susceptibility as gleaned from studies of three hereditary syndromes: basal cell nevus syndrome, familial melanoma/dysplastic nevus syndrome, and xeroderma pigmentosum. We provide a brief synopsis of the recent findings related to these syndromes in an attempt to illustrate several emerging ...
A C, Halpern, J F, Altman
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Genetic Predisposition for Gynecologic Cancers
Clinical Obstetrics & GynecologyHereditary cancer syndromes (HCS) are responsible for up to 10% of all cancers. At present, the majority of cancer susceptibility testing is initiated after a cancer diagnosis. There exists a significant opportunity for primary care providers including general obstetrician-gynecologists to engage in hereditary cancer risk assessment through adequate ...
Tavia, González Peña, Marilyn, Huang
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