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Genetic predisposition to colorectal cancer
Nature Reviews Cancer, 2004High-penetrance mutations in several genes have been identified that contribute to hereditary colorectal cancer. The role of these mutations in cancer pathogenesis is well understood and their detection is successfully used in clinical diagnosis. In stark contrast, our understanding of the influence of low-penetrance mutations that account for most of ...
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Genetic predisposition to cancer
1996Evidence that inherited susceptibility plays a role in the risk of malignancy comes from three separate sources. These observations are that: 1. In some syndromes which are rare in the general population but which are clearly genetically determined, there is a dramatically increased risk of cancer in gene carriers over and above that of the ...
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Genetic Predisposition to IDDM
Clinical Reviews in Allergy & Immunology, 2000S, Caillat-Zucman, J F, Bach
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[Genetic predisposition for Alzheimer's disease].
Therapeutische Umschau. Revue therapeutique, 1996Alzheimer's disease comprises senile and presenile dementia. Aetiologically the disease is heterogeneous but has common clinical and pathological characteristics. Furthermore, in patients with a family history of dementia, its incidence is higher than in the general population.
M, Staufenbiel, E, Pombo-Villar
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