Results 281 to 290 of about 353,849 (343)

Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The patent foramen ovale (PFO), present in 25% of the population, can cause paradoxical embolism and stroke. Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter‐atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy.
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Georgios Tzimas, Ioannis Skalidis, David Meier, Panagiotis Antiochos, Panagiotis Kostakis, Efthymia Pavlou, Francesco Perone, Georgios Tsivgoulis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis   +13 more
wiley   +1 more source

Physical Frailty, Genetic Predisposition, and Incident Heart Failure. [PDF]

JACC Asia
Shi Q, Huang J, Wan J, Zhong Z, Sun Y, Zhou Y, Li J, Tan X, Yu B, Lu Y, Wang N.   +10 more
europepmc   +1 more source

Personal Factors and Career Decision Self‐Efficacy of Postsecondary International Students: The Moderating Role of Cultural Adjustment

The Career Development Quarterly, EarlyView.
ABSTRACT Guided by social cognitive career theory, the current study aims to examine the effect of international students’ personal factors on their career decision self‐efficacy (CDSE) in a postsecondary educational context. We also examine the moderating effect of their cultural adjustment on the relationships between their personal factors and CDSE.
Dae Seok Chai, Sunyoung Park
wiley   +1 more source

The Impact of X‐ray Damage in Chemical Crystalline Materials and New Opportunities for Small Molecule Serial Crystallography

Chemistry – A European Journal, EarlyView.
The impact of X‐ray damage in chemical crystals was minimised by the introduction of area detectors in the late 20th‐century. Now, ever‐brighter X‐ray sources are re‐establishing X‐ray damage as a key challenge. This article reviews recent observations of X‐ray‐induced processes in chemical samples and discusses state‐of‐the‐art methodologies for their
Sam G. Lewis, Mark R. Warren, Lauren E. Hatcher   +2 more
wiley   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

The role of C-reactive protein and genetic predisposition in the risk of psoriasis: results from a national prospective cohort. [PDF]

BMC Rheumatol
Li H, Zhang H, Zhao X, Huang J, Zhang J, Liu Z, Wen J, Qin S.   +7 more
europepmc   +1 more source

Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome [PDF]

, 2015
't Kint de Roodenbeke, Daphné, Berlière, Martine, Claes, Kathleen, Hulstaert, Frank, Janin, Nicolas, Matthijs, Gert, Poppe, Bruce, Robays, Jo, Stordeur, Sabine, Van Maerken, Tom, Wildiers, Hans   +10 more
core  

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition. [PDF]

Neurobiol Aging
Miranda GG, Gonen C, Kraft JN, Rodrigue KM, Kennedy KM.   +4 more
europepmc   +1 more source

RAB19, SERPINB9P1, and Pancreatitis in Patients Taking Azathioprine in Routine Clinical Practice: Genome and Transcriptome‐Wide Association Studies

Clinical Pharmacology &Therapeutics, EarlyView.
Azathioprine is used to treat several inflammatory and autoimmune diseases. However, its use is limited by serious adverse events, including acute pancreatitis. Prior studies have found an association between the HLA region and thiopurine‐induced acute pancreatitis (TIAP); however, in clinical practice, many patients with pancreatitis do not meet this ...
Shailja C. Shah, Tyler S. Reese, Laura L. Daniel, Jacy Zanussi, Alyson L. Dickson, Puran Nepal, Ran Tao, Tyne Miller‐Fleming, Peter Straub, Jennifer Maizel, Adriana M. Hung, Wei‐Qi Wei, Elizabeth J. Phillips, Nancy J. Cox, C. Michael Stein, QiPing Feng, Cecilia P. Chung   +16 more
wiley   +1 more source