Results 301 to 310 of about 353,849 (343)
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Genetics of melanoma predisposition
British Journal of Dermatology, 2008Over the past 10 years, our understanding of melanoma at the molecular level has blossomed with the advent of genomic technologies. The enormous enthusiasm for the Human Genome Project is slowly being replaced by an even greater excitement for the unravelling of disease genomes, including melanoma.
T.L. Hocker +3 more
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Genetic predisposition in pancreatitis
Current Opinion in Pediatrics, 2018Purpose of review Genetic mutations are the primary cause for acute recurrent (ARP) and chronic pancreatitis in children. Further, our medical approach for many diseases is changing from a one-drug therapy to more individualized therapeutic strategies.
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Genetic predisposition to sarcoidosis
Journal of AutoimmunitySarcoidosis is a complex systemic disease with clinical heterogeneity based on varying phenotypes and natural history. The detailed etiology of sarcoidosis remains unknown, but genetic predisposition as well as environmental exposures play a significant role in disease pathogenesis.
Shu-Yi, Liao +2 more
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Genetic Predisposition, Humans
2020The translation from genetic knowledge to a molecular understanding of disease is contributing to the development of improved diagnostic and therapeutic products. Here, we briefly cover the localisation of autoimmune disease-associated loci and examine recent progress in molecular understanding of autoimmune disease that has been facilitated by these ...
Jordan, Margaret A., Baxter, Alan G.
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Genetic predisposition to cancer
BMJ, 1996Evidence that inherited susceptibility plays a role in the risk of malignancy comes from three separate sources. These observations are that: 1. In some syndromes which are rare in the general population but which are clearly genetically determined, there is a dramatically increased risk of cancer in gene carriers over and above that of the ...
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Genetic Predisposition and Genetic Susceptibility
2011More attention has been paid to the inherited nature of malignant tumors in children and adolescents, lately. Children with rare tumors may be at an increased risk of cancer because of a known cancer predisposition syndrome as Li-Fraumeni syndrome in case of adrenocortical tumors or multiple endocrine neoplasia (MEN2) in case of medullary thyroid ...
Ines B. Brecht, Johannes H. M. Merks
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Genetic Testing for Cancer Predisposition
Annual Review of Medicine, 2001▪ Abstract Clinical cancer genetics is becoming an integral part of the care of cancer patients. This review describes the clinical aspects, genetics, and clinical genetic management of most of the major hereditary cancer susceptibility syndromes. Multiple endocrine neoplasia type 2, von Hippel-Lindau disease, and familial adenomatous polyposis are ...
Charis Eng +2 more
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Genetic Testing for Cancer Predisposition
Cancer Nursing, 2002The onslaught of genetic innovations in the past decade has resulted in the ongoing identification of a spectrum of genes, some of which, when mutated, result in cancer susceptibility. The impact of these discoveries on healthcare provides an opportunity to enhance health promotion and long-term health outcomes by identifying at-risk individuals before
Barbara B. Biesecker +1 more
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Genetic Predisposition to Gallbladder Stones
Seminars in Liver Disease, 2007Geographic and ethnic differences in gallstone prevalence rates and familial clustering of cholelithiasis imply that genetic factors influence the risk of gallstone formation. Recently, twin, family, and linkage studies confirmed a genetic predisposition to the development of symptomatic gallstones. In rare instances, mutations in single genes confer a
Frank Lammert, Henning Wittenburg
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Genetic Predisposition to West Syndrome
Epilepsia, 1993Summary:To determine the recurrence risk of West syndrome (WS), we studied the familial antecedents of consecutively referred patients. Among siblings, there was an increased incidence of WS but not of febrile convulsions. Familial incidence of epilepsy was intermediate between the epileptic and nonepileptic control groups.
Nicole Pajot +5 more
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