Results 31 to 40 of about 353,849 (343)

Androgenetic alopecia: a review [PDF]

, 2017
Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism
Caro, Gemma, Fortuna, MARIA CATERINA, Lenzi, Andrea, Lolli, Francesca, Lombardo, Francesco, Pallotti, Francesco, Rossi, Alfredo, Sansone, Andrea   +7 more
core   +1 more source

Genetic Predisposition to Solid Pediatric Cancers

Frontiers in Oncology, 2020
Progresses over the past years have extensively improved our capacity to use genome-scale analyses—including high-density genotyping and exome and genome sequencing—to identify the genetic basis of pediatric tumors.
Mario Capasso, Mario Capasso, Annalaura Montella, Matilde Tirelli, Matilde Tirelli, Teresa Maiorino, Teresa Maiorino, Sueva Cantalupo, Sueva Cantalupo, Achille Iolascon, Achille Iolascon   +10 more
doaj   +1 more source

Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies [PDF]

, 2014
Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals
Curhan, Gary C., Flint, Alan, Forman, John P., Hu, Frank B., Jensen, Majken K., Qi, Lu, Qi, Qibin, Rimm, Eric B.   +7 more
core   +1 more source

Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank

BMC Medicine, 2023
Background The predictive relationship between mild-to-moderate alcohol consumption and the risk of incident atrial fibrillation (AF) remains controversial.
Chan Soon Park, Jaewon Choi, JungMin Choi, Kyung-Yeon Lee, Hyo-Jeong Ahn, Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Soo Heon Kwak, Seil Oh   +9 more
doaj   +1 more source

The Familial Clustering of Age at Menarche in Extended Twin Families [PDF]

, 2007
The timing of puberty is complex, possibly involving many genetic factors that may interact with environmental influences. Familial resemblance for age at menarche was studied in a sample of 4,995 female twins, 1,296 sisters, 2,946 mothers and 635 female
A Must, A Pickles, B Towne, CL Sisk, DB Pillemer, DI Boomsma, Dorret I. Boomsma, DS Falconer, DZ Loesch, EB Greif, FJP Ebling, FL Schmidt, G Willemsen, G Wyshak, J Kaprio, JH Stubbe, JL Jinks, JM Meyer, JM Vink, JR Koopmans, L Ibanez, L Zacharias, MR Palmert, SA Treloar, SM Berg van den, SR Ojeda, Stéphanie M. van den Berg   +26 more
core   +18 more sources

Stroke genetics: prospects for personalized medicine. [PDF]

, 2012
Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke ...
A Gschwendtner, A Hassan, A Helgadottir, A Helgadottir, A Joutel, A Viswanathan, AB Singleton, AJ Bowes, AV Shirodkar, B Rohrer, C Bellenguez, CAPRIE Steering Committee, CS Ku, D Sibbing, DF Gudbjartsson, DJ Klionsky, DK Wysowski, DL Bhatt, DR Holmes Jr, DS Budnitz, E Flossmann, G Paré, HC Diener, HS Markus, HS Markus, Hugh S Markus, J Hardy, JA Johnson, JB Olesen, JF Meschia, JL Mega, JN Hirschhorn, JT O'Brien, L Wang, M Dichgans, M Kubo, M Serizawa, MA Ikram, MV Holmes, P Jerrard-Dunne, P Kraft, P Polychronopoulos, PC Ng, RL Sacco, RS Epstein, S Bevan, S Gretarsdottir, S Gretarsdottir, S Lanfranconi, S Olsson, S Seshadri, S Seshadri, SE Nissen, The International Warfarin Pharmacogenetics Consortium, VG Manolopoulos, VL Roger   +55 more
core   +2 more sources

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). [PDF]

, 2011
We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia.
C Preudhomme, Colin G Steward, Daniela T Pilz, Dimitra Dafou, F-Y Tsai, Fiona C Connell, Glen Brice, Ines Martinez-Corral, M Haugas, M Khandekar, Michael A Simpson, ML Smith, NP Rodrigues, P Callier, Peter Lunt, Peter S Mortimer, Pia Ostergaard, Q Tong, R Zheng, Richard C Trembath, Russell Keenan, S Mansour, S-J Zhang, Sahar Mansour, Sarah Smithson, Shirley Hodgson, Steve Jeffery, T Pabst, Taija Makinen, Tatjana Kilo, Victoria A Murday, W-J Song, Wesley J Woollard   +32 more
core   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]

, 2020
Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D., Bell, J.D., Thomas, E.L., Thomas, E.L., Whitcher, B., Whitcher, B., Yaghootkar, H., Yaghootkar, H.   +7 more
core   +2 more sources

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants [PDF]

, 2017
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index ...
Anderson, Jana, Bailey, Mark E.S., Celis-Morales, Carlos, Gill, Jason M.R., Gray, Stuart, Guo, Yibing, Iliodromiti, Stamatina, Lyall, Donald M., Mackay, Daniel F., Pell, Jill, Petermann, Fanny, Sattar, Naveed, Steell, Lewis, Welsh, Paul   +13 more
core   +1 more source

Slipped Capital Femoral Epiphysis. A Report of 4 Cases Occurring in One Family [PDF]

, 1998
We describe slipped capital femoral epiphysis in 4 members of a black, obese family, who were all first-degree relatives. The aetiology of slipped capital femoral epiphysis is unknown, although it is thought to be multifactorial.
Gomes, AR, Lopes, G, Moreira, JF, Neves, MC   +3 more
core   +1 more source