Results 41 to 50 of about 372,458 (325)
Children, 2023 Background: Primary lactose intolerance (PLI) is characterized by the inability to digest lactose. Homozygotes for the lactase gene polymorphisms (CC or GG) are considered to be genetically predisposed to PLI. Still, symptoms may only be present later in
Corina Pienar +6 more
doaj +1 more source
Genetic predisposition of cholesterol gallstone disease
Annals of Hepatology, 2006 Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems.
Alejandro Hernández-Nazará +4 more
doaj +1 more source
Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. [PDF]
, 2013 It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are due to both genetic and environmental factors. Animal studies provide important translational models for elucidating specific genetic or environmental factors ...
Ashwood, P +5 more
core +2 more sources
Genetic predisposition in nonalcoholic fatty liver disease [PDF]
Clinical and Molecular Hepatology, 2017 Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic ...
Silvia Sookoian, Carlos J. Pirola
doaj +1 more source
Leveraging eQTLs to identify individual-level tissue of interest for a complex trait.
PLoS Computational Biology, 2021 Genetic predisposition for complex traits often acts through multiple tissues at different time points during development. As a simple example, the genetic predisposition for obesity could be manifested either through inherited variants that control ...
Arunabha Majumdar +8 more
doaj +1 more source
Genetic predisposition to prostate cancer [PDF]
British Medical Bulletin, 2016 Prostate cancer (PrCa) is the commonest non-cutaneous cancer in men in the UK. Epidemiological evidence as well as twin studies points towards a genetic component contributing to aetiology.Key recently published literature.A family history of PrCa doubles the risk of disease development in first-degree relatives.
Benafif, S, Eeles, R
openaire +3 more sources
Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk
Pediatric Blood &Cancer, EarlyView.ABSTRACT Children with congenital heart disease (CHD) have elevated neuroblastoma (NB) risk, potentially due to shared neural crest origins. We analyzed rare exonic de novo single‐nucleotide variants in 702 CHD and 454 NB trios from the Neuroblastoma Epidemiology in North America Study, Gabriella Miller Kids First Program, and a published cohort. Seven
Ji Yun Tark +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Anaplastic sarcoma of the kidney (ASK) is a DICER1‐associated malignant tumor presumed to arise in a benign precursor, pediatric cystic nephroma (PCN). However, the initial oncogenic alteration(s) associated with malignant transformation are unknown.
Nahir Cortes‐Santiago +6 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Children undergoing allogeneic stem cell transplantation often receive off‐label rituximab treatment for Epstein–Barr virus reactivation, using adult dosing without pediatric evidence. This project aims to develop a clinical decision support tool (CDSS) that provides evidence‐based dosing scenarios by analyzing real‐world patient data.
Birgit Burkhardt +2 more
wiley +1 more source
Whither Pediatric Research and Predisposition Genetic Testing? [PDF]
, 2006 [À l'origine dans / Was originally part of : CRDP - Droit, biotechnologie et rapport au milieu]Research in which children undergo genetic testing for predisposition to adult-onset diseases or disorders can lead to a better understanding of these ...
Avard, Denise +2 more
core +2 more sources