Results 51 to 60 of about 364,926 (322)

Behavioural Genetics in Criminal Cases: Past, Present and Future [PDF]

, 2006
Researchers studying human behavioral genetics have made significant scientific progress in enhancing our understanding of the relative contributions of genetics and the environment in observed variations in human behavior. Quickly outpacing the advances
Bernet, William, Farahany, Nita A.
core   +1 more source

Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. [PDF]

, 2013
It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are due to both genetic and environmental factors. Animal studies provide important translational models for elucidating specific genetic or environmental factors ...
Ashwood, P, Berman, RF, Careaga, M, Onore, CE, Rushakoff, JA, Schwartzer, JJ   +5 more
core   +2 more sources

Genetic Predisposition to Asthma and Atopy

Respiration, 2005
A large number of studies have tried to identify heritable components in the susceptibility to asthma and atopy phenotypes. This review examines the evidence of multigenetic inheritance for these conditions. We identified in the literature at least 372 gene-disease association studies for asthma and 124 for atopy published in the last 6 years.
Contopoulos-Ioannidis, D. G., Kouri, I. N., Ioannidis, J. P.   +2 more
openaire   +3 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Immunohistochemical Expression of p53 Gene and Clinicopathological Assessment of Low-grade Serous Ovarian Cancer and High-grade Serous Ovarian Cancer: A Cohort Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Ovarian cancer is a significant global health concern for women. More than 85-90% of ovarian cancer cases originates from epithelial causes. Dysfunctional p53 is a hallmark of many cancers, including ovarian cancer.
Geeta Bazard, Minakshi Vashist, Sunita Singh, Gulshan Rohilla, Nidhi Paliwal   +4 more
doaj   +1 more source

Interest in Cancer Predisposition Testing and Carrier Screening Offered as Part of Routine Healthcare Among an Ethnically Diverse Sample of Young Women

Frontiers in Genetics, 2022
Sequencing technologies can inform individuals’ risks for multiple conditions, supporting population-level screening approaches. Prior research examining interest in genetic testing has not generally examined the context of population-based approaches ...
Kimberly A. Kaphingst, Kimberly A. Kaphingst, Jemar R. Bather, Brianne M. Daly, Daniel Chavez-Yenter, Daniel Chavez-Yenter, Alexis Vega, Wendy K. Kohlmann   +7 more
doaj   +1 more source

Whither Pediatric Research and Predisposition Genetic Testing? [PDF]

, 2006
[À l'origine dans / Was originally part of : CRDP - Droit, biotechnologie et rapport au milieu]Research in which children undergo genetic testing for predisposition to adult-onset diseases or disorders can lead to a better understanding of these ...
Avard, Denise, Farkas Patenaudel, Andrea, Sénécal, Karine   +2 more
core   +2 more sources

Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]

, 2015
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina, Ferrer, Marcela Maria, Giliberto, Florencia, Luce, Leonela Natalia, Ottaviani, Daniela, Parma, Diana Lidia, Szijan, Irena   +6 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modelling the Interplay between Lifestyle Factors and Genetic Predisposition on Markers of Type 2 Diabetes Mellitus Risk [PDF]

, 2015
The risk of developing type 2 diabetes mellitus (T2DM) is determined by a complex interplay involving lifestyle factors and genetic predisposition. Despite this, many studies do not consider the relative contributions of this complex array of factors to ...
Ambrosini, GL, Caterson, ID, Fuller, NR, Hauner, H, Holzapfel, C, Jebb, SA, Loos, RJ, Solis-Trapala, I, Walker, CG   +8 more
core   +2 more sources