Results 61 to 70 of about 364,926 (322)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD
Hepatology Communications, 2022 Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity.
Theresia M. Schnurr +10 more
doaj +1 more source
Are Genetics Involved in the Development of Multisystem Inflammatory Syndromes in Children?
Trends in Pediatrics, 2022 The relationship between Multisystem Inflammatory Syndrome in Children (MIS-C) and genetic predisposition is not well established. The aim of this article emphasize the presence of genetic predisposition in MIS-C by presenting two sibling cases from two
Sevcan Ipek, Ufuk Utku Güllü
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Genetic Influences on Snoring: A Narrative Review [PDF]
Sleep Medicine ResearchSnoring is a sound that results from vibrations of soft tissues in the narrowed upper airway during sleep. Obstructive sleep apnea (OSA) is a disease entity that must be properly treated.
Sun A Han, Jeong-Whun Kim
doaj +1 more source
Genetics and Economic Mobility [PDF]
, 2008 Presents a literature review on the link between genetic traits, such as cognitive skills, health, mental health, personality, and appearance, and academic and economic success.
Jessica Kronstadt
core
Genetic Predispositions and Childhood Cancer [PDF]
Environmental Health Perspectives, 1998 This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the
openaire +3 more sources
Advanced Chinese Medicine, EarlyView.Abstract Rheumatoid arthritis (RA) is a chronic, highly disabling autoimmune disease. Although modern medical treatments have made progress, challenges such as suboptimal efficacy, relapse, difficulties in comorbidity management, and side effects persist.
Dier Jin +8 more
wiley +1 more source
On Sin, Repentance, Christian Nurture, And The Genetics of Personality [PDF]
, 2012 Dean Homer\'s description of the genetics of personality includes two components: temperament and character. Temperament is a product of the interaction of the individual\'s genes with early stimuli, whereas character is formed by parenting, social ...
Keefer, Robert A.
core +1 more source