Results 71 to 80 of about 353,849 (343)

Genetic predisposition to prostate cancer [PDF]

British Medical Bulletin, 2016
Prostate cancer (PrCa) is the commonest non-cutaneous cancer in men in the UK. Epidemiological evidence as well as twin studies points towards a genetic component contributing to aetiology.Key recently published literature.A family history of PrCa doubles the risk of disease development in first-degree relatives.
Benafif, S, Eeles, R
openaire   +4 more sources

Особенности рецепторного статуса опухолей у больных с различной степенью наследственной предрасположенности к раку молочной железы [PDF]

, 2009
У 95 больных раком молочной железы (РМЖ) с разной степенью отягощенности родословных онкологической патологией проведено сопоставление результатов иммуногистохимического исследования экспрессии рецепторов эстрогенов, прогестерона и белка Неr2/neu ...
Петрова, О.В., Проняков, В.И., Соркин, В.М.   +2 more
core  

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease [PDF]

, 2018
Background Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes ...
A Liberzon, A McKenna, AA Al Olama, AG Vinuesa de, AH Ramos, AJ Vickers, B Sharma, C Cybulski, C Cybulski, C Deisenroth, CC Pritchard, Christopher A. Haiman, Clara Cieza-Borrella, CM Ewing, CM Gay, D Leongamornlert, D Li, Daniel A. Leongamornlert, David V. Conti, DC Koboldt, E Castro, E Castro, E Ruark, Edward J. Saunders, FR Schumacher, G Jun, Ian Whitmore, J Karar, J Li, J Niewiarowska, JB Hjelmborg, JI Jun, JL Beebe-Dimmer, K Yumoto, Koveela Govindasami, L Finney, LA Mucci, M Kircher, M Lek, M Martin, M Mongiat, MA Quintana, MA Quintana, Mark N. Brook, Martina Mijuskovic, P Dell’Oglio, PC Sham, R Bhati, R Lozano, R Na, RA Eeles, RD Wood, Rosalind A. Eeles, S Carbon, S Lee, S Purcell, Sarah Wakerell, SI Cunha, SM Gogarten, SN Hart, T Walsh, T Wei, The 1000 Genomes Project Consortium., Tokhir Dadaev, X Chang, X Liu, X Zhan, X Zheng, Y Gong, Z Kote-Jarai, Z Kote-Jarai, Zsofia Kote-Jarai   +71 more
core   +2 more sources

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima   +8 more
wiley   +1 more source

Symposium 6: HLA and Non-HLA genetic predisposition

Revista de la Sociedad Argentina de Diabetes, 2020
Symposium 6: Autoimmune diabetes: heterogeneity in its clinical presentations HLA and Non-HLA genetic predisposition Type 1 diabetes is a multifactorial autoimmune disease.
Gloria Cerrone
doaj   +1 more source

Myelodysplastic syndrome with genetic predisposition

BLOOD RESEARCH, 2021
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of clonal blood disorders characterized by ineffective hematopoiesis, cytopenia, dysplasia, and an increased risk of acute myeloid leukemia (AML). A growing number of inherited genetic loci that contribute to MDS/AML development are rapidly being identified. As genetic sequencing has become
openaire   +4 more sources

Behavioural Genetics in Criminal Cases: Past, Present and Future [PDF]

, 2006
Researchers studying human behavioral genetics have made significant scientific progress in enhancing our understanding of the relative contributions of genetics and the environment in observed variations in human behavior. Quickly outpacing the advances
Bernet, William, Farahany, Nita A.
core   +1 more source

Genomics knowledge and attitudes among European public health professionals. Results of a cross-sectional survey [PDF]

, 2020
Background The international public health (PH) community is debating the opportunity to incorporate genomic technologies into PH practice. A survey was conducted to assess attitudes of the European Public Health Association (EUPHA) members towards their
Baccolini, V., Barnhoorn, F., D'Andrea, E., de Vito, C., Marco, M. D., Marzuillo, C., Paget, D. Z., Pitini, E., Rosso, A., Unim, B., Villari, P.   +10 more
core   +2 more sources

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source

Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective This study analyzed longitudinal trajectories of soluble Flt1 (sFlt1) levels, placenta growth factor (PlGF) levels, and sFlt1:PlGF ratios in a cohort of pregnant patients with systemic lupus erythematosus (SLE). Methods Blood samples were collected (14–18, 24–26, 30–32, 34–36, and 38–40 weeks), stored at −80°C, and evaluated for serum levels ...
Nilson R. de Jesús, Guilherme R. de Jesús, Marcela I. Lacerda, Flávia C. dos Santos, Jeane de S Nogueira, Luiz Cristóvão Porto, Evandro S. F. Coutinho, Evandro M. Klumb   +7 more
wiley   +1 more source