Results 71 to 80 of about 364,926 (322)

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice. [PDF]

, 2016
Background: P. aeruginosa is one of the top three causes of opportunistic human bacterial infections. The remarkable variability in the clinical outcomes of this infection is thought to be associated with genetic predisposition.
A Bragonzi, A Bragonzi, A Bragonzi, A Corken, A Darvasi, Alessandra Bragonzi, C Cigana, C Morissette, C Morissette, CC Elbers, Cristina Cigana, CS Haley, D Nguyen, DL Demeo, DM Menge, E Amiel, EE Smith, F Iraqi, F Iraqi, FA Iraqi, FA Iraqi, Fuad A. Iraqi, GA Churchill, GR Cutting, GS Cooke, H Shinohara, I Bianconi, Ida De Fino, J Dupuis, JB Lyczak, JE Pennington, JM Collaco, K Sapru, K Tremblay, Karl W. Broman, KW Broman, L Guillot, LD Hazlett, Lorenza Spagnuolo, M Hernandez-Valladares, M Munoz, M Simone De, M Tam, M Verdrengh, MA Jong de, Maura De Simone, ML Drumm, N Lorè, NI Lore, Nicola Ivan Lorè, R Mashima, R Mashima, R Williams, S Aerts, S Gruenheid, S Worgall, SL Cheng, SL Gellatly, SM Vidal, TT Wu, V DeRose, Y Moreau, Y Zhan   +62 more
core   +1 more source

Genetic Predisposition to Infectious Disease [PDF]

Cureus, 2018
In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades ...
openaire   +3 more sources

Genetic predisposition to prostate cancer [PDF]

British Medical Bulletin, 2016
Prostate cancer (PrCa) is the commonest non-cutaneous cancer in men in the UK. Epidemiological evidence as well as twin studies points towards a genetic component contributing to aetiology.Key recently published literature.A family history of PrCa doubles the risk of disease development in first-degree relatives.
Benafif, S, Eeles, R
openaire   +4 more sources

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

Myelodysplastic syndrome with genetic predisposition

BLOOD RESEARCH, 2021
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of clonal blood disorders characterized by ineffective hematopoiesis, cytopenia, dysplasia, and an increased risk of acute myeloid leukemia (AML). A growing number of inherited genetic loci that contribute to MDS/AML development are rapidly being identified. As genetic sequencing has become
openaire   +4 more sources

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

CLINICAL AND GENETIC PARALLELS ALONG CELIAC DISEASE AMONG TOMSK CHILDREN

Педиатрическая фармакология, 2007
The article is devoted to the analysis of the genetic predisposition to celiac disease. The authors studied the associations of the HLA genes and modifier genes of the immune response (interleukine 1, inter leukine 1 receptor antagonist, inter leukine 4,
E.I. Kondrat’eva, V.P. Puzyrev, L.P. Nazarenko, A.A. Rudko, G.N. Yankina, E.V. Loshkova   +5 more
doaj   +2 more sources

Genetic Predisposition to Cancer

British Journal of Cancer, 2006
The US Surgeon General's ‘Family History Initiative', launched in 2004, underlines increasing public and professional awareness of the importance of knowing the health history of your close relatives and the benefits this can bring to the health care of family members.
openaire   +2 more sources