TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah +2 more
wiley +1 more source
Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks [PDF]
arXiv, 2016 Most disorders are caused by a combination of multiple genetic and/or environmental factors. If two diseases are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle how much genetic or environmental risk factors contribute to the pathogenesis of 358 individual diseases ...
arxiv
American Journal of Hematology, EarlyView.ABSTRACT Allogeneic hematopoietic stem‐cell transplantation (HCT) remains the only potentially curative therapy for patients with myelodysplastic neoplasms (MDS) and myelofibrosis (MF) and is the standard care for eligible patients with higher‐risk disease. Despite significant advancements, both diseases pose unique challenges due to their clinical and
Nico Gagelmann, Nicolaus Kröger
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Considering the complications related to alcohol withdrawal syndrome (AWS) such as seizure, delirium tremens and cardiac arrhythmia, it is important to identify the risk of delirium tremens (DT) following AWS and enhance preventive strategies. We observed the characteristics of quantitative electroencephalography in patients with AWS, specifically who ...
Jee‐Eun Yoon +3 more
wiley +1 more source
Topics of Interest in Women With Myeloproliferative Neoplasms
American Journal of Hematology, EarlyView.Women with MPN: life‐cycle phases, specific risks, and influencing factors. ABSTRACT Overview Sex and gender have emerged as central modifiers of disease biology, phenotype, and clinical outcomes in myeloproliferative neoplasms (MPNs). This review will uniquely highlight issues affecting women with MPN and articulate their relevant determinants ...
Natasha Szuber +2 more
wiley +1 more source
Genetic Bases for Predisposition to Common Multifactorial Disease in Man. Part II [PDF]
, 2007 Rumena Petkova +2 more
openalex +1 more source
Genetic variability shapes the alternative pathway complement activity and predisposition to complement‐related diseases [PDF]
, 2022 Santiago Rodrı́guez de Córdoba
openalex +1 more source
Genetic predisposition to alcoholic liver disease. [PDF]
Gut, 1992 C.P. Day, M F Bassendine
openaire +3 more sources
Machine Learning Models for the Identification of Cardiovascular Diseases Using UK Biobank Data [PDF]
arXivMachine learning models have the potential to identify cardiovascular diseases (CVDs) early and accurately in primary healthcare settings, which is crucial for delivering timely treatment and management. Although population-based CVD risk models have been used traditionally, these models often do not consider variations in lifestyles, socioeconomic ...
arxiv
Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India [PDF]
, 2010 Soujatya Dhar +5 more
openalex +1 more source