Results 171 to 180 of about 2,740,375 (371)

The effect of genetic predisposition to Alzheimer’s disease and related traits on recruitment bias in a study of cognitive ageing [PDF]

open access: green, 2023
Lina Gómez   +10 more
openalex   +1 more source

Dupuytren\u27s Disease [PDF]

open access: yes, 2017
Dupuytren\u27s disease (DD) is a chronic condition in which fibrosis of tissue beneath the palm of the hand occurs. Causes and mechanisms of this disease\u27s development are still not entirely understood.
Pinckney, Leah C.
core   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin   +11 more
wiley   +1 more source

GENETIC FOUNDATIONS OF THE BRONCHIAL ASTHMA

open access: yesПедиатрическая фармакология, 2008
The article overviews the results of the studies of the genetic foundations of predisposition to the bronchial asthma. The authors provide detailed information on the molecular and genetic mechanisms of the bronchial asthma, roles performed by the ...
A.Yu. Asanov   +4 more
doaj   +2 more sources

An investigation of the progression from Barrett's esophagus to adenocarcinoma [PDF]

open access: yes, 2016
Barrett's esophagus is a metaplasia of the epithelium of the lower esophagus from a normal squamous appearance to a columnar appearance more typically found in the stomach. It is normally caused by prolonged gastric reflux. While Barrett's esophagus is
Palmese, Scott Joseph
core   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

open access: yesAdvanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao   +18 more
wiley   +1 more source

Genetic Predisposition to Higher Blood Pressure Increases Risk of Incident Hypertension and Cardiovascular Diseases in Chinese [PDF]

open access: bronze, 2015
Xiangfeng Lu   +26 more
openalex   +1 more source

Development of a person-centred digital platform for the long-term support of people living with an adult-onset genetic disease predisposition: a mixed-methods study protocol [PDF]

open access: gold, 2023
Stephanie Best   +11 more
openalex   +1 more source

Genetic predisposition of ischaemic heart disease [PDF]

open access: yesPostgraduate Medical Journal, 1997
Kamejiro Yamashita   +2 more
openaire   +2 more sources

Genetic Information and the Workplace - Full Report [PDF]

open access: yes, 1998
Joint Agency ReportGeneticInfoWorkplace1998.pdf: 800 downloads, before Oct.
Department of Health and Human Services, U.S.   +2 more
core   +1 more source

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