Results 181 to 190 of about 2,712,849 (369)

Cohesins: Crossroad Between Cornelia de Lange Spectrum and Cancer Predisposition

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The cohesin complex plays crucial roles in DNA repair, chromatid separation, and gene transcription regulation. Pathogenic variants in cohesins or dysfunctional transcriptional regulators lead to cohesinopathies, a broader group of disorders including Cornelia de Lange Spectrum (CdLSp), for which the prevalence of cancer cases remains unclear.
Laura Rigotti, Stefano Rebellato, Antonella Lettieri, Silvia Castiglioni, Milena Mariani, Simona Totaro, Claudia Saitta, Cristina Gervasini, Grazia Fazio, Valentina Massa, Giovanni Cazzaniga, Angelo Selicorni   +11 more
wiley   +1 more source

Development in Prescriptions of Contraindicated and Potentially Harmful QT Interval–Prolonging Drugs in a Large Geriatric Inpatient Cohort From 2011 to 2021

Clinical Pharmacology &Therapeutics, Volume 113, Issue 2, Page 435-445, February 2023., 2023
Regulatory authorities put major emphasis on QT (interval)–prolonging properties of new molecular entities. Product information/Summaries of Product Characteristics (SmPCs) of multiple drugs contain warnings or contraindications regarding QT prolongation, e.g., on coadministration of QT‐prolonging drugs (QT drugs).
Melanie I. Then, Thomas Tümena, Anna Sledziewska, Karl‐Günter Gaßmann, Renke Maas, Martin F. Fromm   +5 more
wiley   +1 more source

Genetic Predisposition to Higher Blood Pressure Increases Risk of Incident Hypertension and Cardiovascular Diseases in Chinese [PDF]

, 2015
Xiangfeng Lu, Jianfeng Huang, Laiyuan Wang, Shufeng Chen, Xueli Yang, Jianxin Li, Jie Cao, Jichun Chen, Ying Li, Liancheng Zhao, Hongfan Li, Fangcao Liu, Chen Huang, Chong Shen, Jinjin Shen, Ling Yu, Lihua Xu, Jianjun Mu, Xianping Wu, Ji Xu, Dongshuang Guo, Zhengyuan Zhou, Zili Yang, Renping Wang, Jun Yang, Weili Yan, Dongfeng Gu   +26 more
openalex   +1 more source

Development of a person-centred digital platform for the long-term support of people living with an adult-onset genetic disease predisposition: a mixed-methods study protocol [PDF]

, 2023
Stephanie Best, Abdullah Al Mahmud, Shivani Tyagi, Jack C.W. Wheeler, Abdur Rahim Mohammad Forkan, Alexandra Lewis, Muhammad Nadeem Shuakat, Rohit Kaul, Aisha Ward, Nilmini Wickramasinghe, Prem Prakash Jayaraman, Alison H. Trainer   +11 more
openalex   +1 more source

Genetic predisposition of ischaemic heart disease [PDF]

Postgraduate Medical Journal, 1997
Kamejiro Yamashita, M. Odawara, A. Matsunuma   +2 more
openaire   +2 more sources

Potential New Expression Biomarkers for Anorexia Nervosa

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta‐analysis of genome‐wide association studies on AN identified independent risk‐conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated.
Camille Verebi, Nicolas Lebrun, Justine Vily Petit, Odile Viltart, Philibert Duriez, Benjamin Saint‐Pierre, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
wiley   +1 more source

Molecular autopsy of sudden unexplained deaths reveals genetic predispositions for cardiac diseases among young forensic cases [PDF]

, 2016
Nicole Hellenthal, Anna Gaertner, Bärbel Klauke, Lech Paluszkiewicz, Markus Stuhr, Thoralf Kerner, Martin Farr, Klaus Püschel, Hendrik Milting   +8 more
openalex   +1 more source

Genetic Predisposition of Diabetes to Coronary Artery Disease Due to ApoE Gene Polymorphism Using Allele Discrimination Real-Time Analysis as a Diagnostic Tool [PDF]

, 2023
Mohammed Noori Salman, Abdulhussein Alwan Faraj aljanabi, Thekra A. Al-Kashwan   +2 more
openalex   +1 more source

Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive‐compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision‐making, allow for better‐tailored interventions, and avoid treatment failure.
Julia Bäckman, John Wallert, Matthew Halvorsen, Bjorn Roelstraete, Elles de Schipper, Nora I. Strom, Thorstein Olsen Eide, Kira D. Höffler, Manuel Mattheisen, Bjarne Hansen, Gerd Kvale, Kristen Hagen, Jan Haavik, Nordic OCD and Related Disorders Consortium (NORDiC), Julia Bäckman, Long Long Chen, James J. Crowley, Elles de Schipper, Diana Pascal, Jan Haavik, Kristen Hagen, Matthew W. Halvorsen, Bjarne Hansen, Kira D. Höffler, Fredrik Johansson, Anna K. Kähler, Elinor K. Karlsson, Gerd Kvale, Paul Lichtenstein, Kerstin Lindblad‐Toh, Manuel Mattheisen, David Mataix‐Cols, Kathleen Morrill, Christian Rück, Thorstein Olsen Eide, Nora I. Strom, John Wallert, David Mataix‐Cols, Christian Rück, James J. Crowley   +39 more
wiley   +1 more source

AB0007 Shared genetic predisposition in rheumatoid arthritis–interstitial lung disease and familial pulmonary fibrosis [PDF]

, 2017
P.-A. Juge, Raphaël Borie, Caroline Kannengiesser, Steven Gazal, Patrick Revy, Lidwine Wémeau-Stervinou, M Debray, Stefania Ottaviani, S. Marchand‐Adam, Nadia Nathan, Gabriel Thabut, Christophe Richez, Hilario Nunès, Isabelle Callebaut, A. Justet, Pascal Richette, H. Lioté, Yannick Allanore, Olivier Sand, C Dromer, RM Flipo, A. Clément, Jean Sibilia, Baptiste Coustet, Vincent Cottin, Marie‐Christophe Boissier, B. Wallaert, T. Schaeverbeke, DLM Florence, Aline Frazier, Christelle Ménard, Martin Soubrier, Nathalie Saidenberg-Kermanac’h, Dominique Valeyre, Serge Amselem, Cathérine Boileau, B. Crestani, Philippe Dieudé   +37 more
openalex   +1 more source