Results 211 to 220 of about 320,413 (381)

The genetics of mental illness: implications for practice

Bulletin of the World Health Organization, 2000
Many of the comfortable and relatively simple models of the nature of mental disorders, their causes and their neural substrates now appear quite frayed.
Steven E. Hyman
doaj  

P14-057-23 Plant-Based Diets, Genetic Predisposition, and Risk of Non-Alcoholic Fatty Liver Disease

, 2023
Yanling Lv, Shuang Rong, Yan Deng, Wei Bao, Xia Yang, Liegang Liu, Liangkai Chen   +6 more
openalex   +1 more source

SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

Animal Models and Experimental Medicine, EarlyView.
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling, Xilan Dong, Liyan Mao, Chengjun Huang, Linjing Cong, Haizeng Zhang, Jun Cai, Zhenzhen Chen   +7 more
wiley   +1 more source

GENETIC FOUNDATIONS OF THE BRONCHIAL ASTHMA

Педиатрическая фармакология, 2008
The article overviews the results of the studies of the genetic foundations of predisposition to the bronchial asthma. The authors provide detailed information on the molecular and genetic mechanisms of the bronchial asthma, roles performed by the ...
A.Yu. Asanov, L.S. Namazova, V.G. Pinelis, N.V. Zhurkova, N.I. Voznesenskaya   +4 more
doaj  

Multiple low dose streptozotocin‐induced diabetes as a model for studying autoimmune diabetes in humans

Animal Models and Experimental Medicine, EarlyView.
Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica, Suzana Stanisavljević, Dragica Mićanović, Ivana Stojanović, Đorđe Miljković   +4 more
wiley   +1 more source

Midlife Steroid‐Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women

Annals of Neurology, EarlyView.
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐
Rachel F. Buckley, Matthew Scott, Emer R. McGrath, Gillian Coughlan, Mabel Seto, Saptaparni Ghosh, Heidi I. L. Jacobs, Claudia L. Satizabal, Emma Thibault, Vasan Ramachandran, Joanne M. Murabito, Reisa A. Sperling, Keith A. Johnson, Ravi Jasuja, Shalender Bhasin, Sudha Seshadri, Alexa S. Beiser   +16 more
wiley   +1 more source

Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci

Oncogene, 2009
A. Chapelle
semanticscholar   +1 more source

GENETIC PREDISPOSITION TO PERIODONTAL DISEASES: MYTH OR REALITY?

GENETIC PREDISPOSITION TO PERIODONTAL DISEASES: MYTH OR REALITY? Yusupjanova Nigora Davrbek qizi assistant at Central Asian Medical University in Fergana https://doi.org/10.5281/zenodo.15133668 Abstract: Periodontal diseases, including gingivitis and periodontitis, are among the most prevalent oral health conditions worldwide.
openaire   +2 more sources

How do index patients participating in genetic screening programmes for familial hypercholesterolemia (FH) interpret their DNA results?:A UK-based qualitative interview study [PDF]

, 2011
Douglas, Margaret, Finnie, Robert, Hallowell, Nina, Jenkins, Nick, Lawton, Julia, Porteous, Mary, Walker, Simon   +6 more
core   +1 more source

Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The objective of this study was to investigate the relationships among subthalamic nucleus (STN) activity, gait initiation (GI), and freezing of gait (FOG) in patients with Parkinson's disease (PD). Methods We recorded GI and STN local field potentials (LFPs) via externalized cables in 38 patients with PD (35 reporting FOG in daily life ...
Antoine Collomb‐Clerc, Mathieu Yeche, Adèle Demain, Angèle Van Hamme, Claire Olivier, Hayat Belaid, Déborah Ziri, Stéphane Derrey, Sara Fernandez‐Vidal, Katia Lehongre, Carine Karachi, Brian Lau, Marie‐Laure Welter   +12 more
wiley   +1 more source