Results 271 to 280 of about 2,712,849 (369)

Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis. [PDF]

Dialogues Clin Neurosci
Zeng R, Jiang R, Huang W, Wu H, Zhuo Z, Yang Q, Li J, Leung FW, Sha W, Chen H.   +9 more
europepmc   +1 more source

Evolving Recommendations for Patient Populations Among Oncology Medicines: A Quantitative and Qualitative Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
After a medicine has been tested in pivotal trials, regulators, health technology assessment (HTA) organizations, and professional societies make decisions about the patients best served by the medicine. This study assesses how the patient populations for oncology medicines (2010–2023) are defined (1) at trial, (2) regulatory submission, (3) upon ...
Milou A. Hogervorst, Rick A. Vreman, Theresa A. Oduol, Aukje K. Mantel‐Teeuwisse, Wim G. Goettsch, Aaron S. Kesselheim   +5 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Rare germline ATM variants predispose to secondary cancer in chronic lymphocytic leukaemia patients

Cancer Communications, EarlyView.
Anna Petrackova, Jirina Manakova, Romana Nesnadna, Zuzana Kubova, Tomas Papajik, Eva Kriegova   +5 more
wiley   +1 more source

Longitudinal monitoring of class‐switched memory‐B cell proportions identifies plausible germinal center failure in patients with suspected immune disorders

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract A reduced proportion of peripheral class‐switched memory B cells (CSM‐B cells) is presumed to indicate ineffective germinal activity. The extent that this finding corresponds to a plausible germinal center failure pathophysiology in patients not diagnosed with CVID or hyper IgM syndrome is not known.
Vijaya Knight, Olivia Starich, Cullen M. Dutmer, Jordan K. Abbott   +3 more
wiley   +1 more source

Addressing uncertainty in hereditary colorectal cancer: the role of a regional expert multidisciplinary team meeting. [PDF]

Fam Cancer
Varde A, McVeigh T, Cuthill V, Brady AF, DeSouza B, Latchford A, Monahan KJ.   +6 more
europepmc   +1 more source

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Cancer Communications, EarlyView.
Lea Järke, Saskia Weber‐Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer   +15 more
wiley   +1 more source

Associations Between Chronotype, Genetic Susceptibility and Risk of Colorectal Cancer in UK Biobank. [PDF]

J Epidemiol Glob Health
Xie H, Xi Z, Wen S, Zhang W, Liu Y, Zheng J, Feng H, Wu D, Li Y.   +8 more
europepmc   +1 more source

Prediction of success in sports based on assumed individual genetic predisposition: lack of association with the C > T variant in the ACTN3 gene. [PDF]

J Physiol Anthropol
Godina E, Khromov-Borisov N, Bondareva E.   +2 more
europepmc   +1 more source

Prevalence of Rheumatic Heart Disease in First-Degree Relatives of Index-Cases: A Systematic Review and Meta-Analysis. [PDF]

Glob Heart
Mutarelli A, Nogueira GPG, Pantaleao AN, Nogueira A, Giavina-Bianchi B, Fonseca IMG, Nascimento BR, Dutra WO, Levine RA, Nunes MCP, PRIMA Network.   +10 more
europepmc   +1 more source