Results 201 to 210 of about 2,407,465 (287)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Patient Perspectives and Demographic Factors Influencing Non-Participation in a Large Genomics Study. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Presutti RJ, Clapp AD, Vierkant RA, Armasu SM, Kahrizi MS, Bublitz ML, Houwink EJ, Samadder NJ, Sharp RR, Barnhorst M, Boeff DJ, Befus SM, Kruisselbrink T, Lazaridis KN.   +13 more
europepmc   +1 more source

Exploring patient motivations and preferences for medical data sharing with researchers: a simulation study using the iAgree platform. [PDF]

J Am Med Inform Assoc
Keller MS, Nguyen AT, Leder C, Chen Y, Morse B, Schilling LM, Hu D, SooHoo S, Ohno-Machado L.   +8 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Data After Death: Post-Mortem Ethics of Burn Patient Records and Images. [PDF]

J Burn Care Res
Khorsandi J, Mansoury B, Blank L, Ahmed AB, Alkhouri S, Cataldo K, MacDavid J.   +6 more
europepmc   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Human Genetic Information, Genetic Registers and the Subpoena Duces Tecum: Balancing Privacy, Confidentiality and the Administration of Justice [PDF]

Bond Law Review
William Keough
doaj  

Integrating Artificial Intelligence with Global Genomic Resources: A Narrative Review of Implications for Precision Medicine. [PDF]

J Multidiscip Healthc
Alam T, Saha K, Rony MKK, Shahi D, Utsho MR, Hossain A, Ahmed F, Manik MMTG, Anees Sabeena A, Erdei TI.   +9 more
europepmc   +1 more source

Interpretable Machine Learning Framework for Nb─Si Based Alloy Design with Enhanced Fracture Toughness

Advanced Science, EarlyView.
An interpretable machine learning framework integrating SHAP and PDP analysis identifies critical design descriptors from 139 physicochemical features for Nb─Si alloys. The framework achieves <7% prediction error and guides the discovery of Nb38.5Ti38.5Si3Zr18V2 alloy with 22.791 MPa·m1/2 fracture toughness, breaking the 20 MPa·m1/2 barrier.
Dezhi Chen, Chao Xu, Jingyue Yu, Qi Wang, Hongze Fang, Shuo Yin, Turab Lookman, Ruirun Chen   +7 more
wiley   +1 more source

Beyond consent: Reframing ethical governance in genetic data reuse within clinical trials. [PDF]

Perspect Clin Res
Kalikar MV, Dakhale G.
europepmc   +1 more source