Results 91 to 100 of about 3,432,068 (369)

Evolutionary dynamics of insertion sequences in relation to the evolutionary histories of the chromosome and symbiotic plasmid genes of Rhizobium etli populations [PDF]

, 2010
Insertion sequences (IS) are mobile genetic elements that are distributed in many prokaryotes. In particular, in the genomes of the symbiotic nitrogen-fixing bacteria collectively known as rhizobia, IS are fairly abundant in plasmids or chromosomal ...
Bustos, Patricia, Davila, Guillermo, Gonzalez, Victor, Hernandez-Gonzalez, Ismael, Lozano, Luis, Santamaria, Rosa I., Souza, Valeria, Young, J. Peter W.   +7 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Bose-Einstein distribution, condensation transition and multiple stationary states in multiloci evolution of diploid population

, 2010
The mapping between genotype and phenotype is encoded in the complex web of epistatic interaction between genetic loci. In this rugged fitness landscape, recombination processes, which tend to increase variation in the population, compete with selection ...
A. Hartmann, C. Darwin, C. J. Pethick, D. Hartl, E. Ben-Naim, Ginestra Bianconi, J. H. Gillespie, J. Hofbauer, J. Monod, J. S. Yedidia, K. Huang, K. Jain, K. Sneppen, L. Peliti, M. A. Nowak, M. Mézard, Olaf Rotzschke, R. A. Fisher, U. Alon   +18 more
core   +1 more source

Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]

, 2013
African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
A MacLeod, A MacLeod, A MacLeod, A Tait, A Tait, A Tait, A Tait, Andy Tait, Anneli Cooper, Annette MacLeod, BG Spratt, C. Michael R. Turner, CA Oura, Craig W. Duffy, CW Duffy, Daniel K. Masiga, DK Howe, EM Fevre, EM Fevre, F Balloux, F Mathieu-Daude, F Njiokou, FG Razakandrainibe, G Hide, G Hide, G Hide, HK Auty, HV Xong, J Maynard Smith, J Sternberg, Jeremy Sternberg, JJ McNamara, JR Stevens, L Berrang-Ford, L Jenni, L MacLean, L MacLean, L Peacock, L Peacock, Liam J. Morrison, Lindsay Sweeney, LJ Morrison, LJ Morrison, LJ Morrison, LJ Morrison, LM MacLean, Lorna MacLean, M Koffi, M Koffi, M Tibayrenc, M Tibayrenc, M Tibayrenc, NE Anderson, O Balmer, P Paindavoine, R Peakall, RD Page, RE Paul, RJ Pearce, SC Welburn, TJ Anderson, V Jamonneau, W Gibson, W Gibson, W Gibson, W Gibson, W Gibson, W Weir, WC Gibson, WC Gibson, Z Annan   +70 more
core   +6 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Bio-Protocol, 2019
Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis, Sha Cao, Diarmaid Hughes   +2 more
doaj   +1 more source

Genetic recombination in bacteriophage lambda

, 2012
© The Author 2012. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-
C. Hillyar
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The influence of recombination on human genetic diversity. [PDF]

PLoS Genetics, 2006
In humans, the rate of recombination, as measured on the megabase scale, is positively associated with the level of genetic variation, as measured at the genic scale.
Chris C A Spencer, Panos Deloukas, Sarah Hunt, Jim Mullikin, Simon Myers, Bernard Silverman, Peter Donnelly, David Bentley, Gil McVean   +8 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source