Results 121 to 130 of about 3,303,031 (404)

Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination [PDF]

open access: yes, 2008
Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial ...
Bragard, C.   +7 more
core   +3 more sources

The estimation of map distances from recombination values.

open access: yes, 1943
The genetic map is a tool to quantify the distance between genes on a chromosome, based on the observed frequency of crossovers during cell division.
D. D. Kosambi
semanticscholar   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores   +14 more
wiley   +1 more source

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

open access: yesBio-Protocol, 2019
Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis   +2 more
doaj   +1 more source

Analysis of Optimal Recombination in Genetic Algorithm for a Scheduling Problem with Setups [PDF]

open access: yesarXiv, 2014
In this paper, we perform an experimental study of optimal recombination operator for makespan minimization problem on single machine with sequence-dependent setup times ($1|s_{vu}|C_{\max}$). The computational experiment on benchmark problems from TSPLIB library indicates practical applicability of optimal recombination in crossover operator of ...
arxiv  

The role of haplotype complementation and purifying selection in the genome evolution [PDF]

open access: yes, 2010
We discuss two different ways of chromosomes' and genomes' evolution. Purifying selection dominates in large panmictic populations, where Mendelian law of independent gene assortment is valid. If the populations are small, recombination processes are not
Cebrat, Stanislaw   +2 more
core  

Smc5/6 is required for repair at collapsed replication forks. [PDF]

open access: yes, 2006
In eukaryotes, three pairs of structural-maintenance-of-chromosome (SMC) proteins are found in conserved multisubunit protein complexes required for chromosomal organization.
Ampatzidou, Eleni   +3 more
core   +3 more sources

Genetic recombination in Pseudomonas aeruginosa.

open access: yesJournal of General Microbiology, 1955
Summary: Genetic recombination has been shown to occur in Pseudomonas aeruginosa. Crosses between 18 biochemical mutants of 4 strains were studied and, although non-random segregation was found for non-selective markers, it has not yet been possible to ...
B. Holloway
semanticscholar   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1508-1516, May 2025.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Scalability of Genetic Programming and Probabilistic Incremental Program Evolution [PDF]

open access: yes, 2005
This paper discusses scalability of standard genetic programming (GP) and the probabilistic incremental program evolution (PIPE). To investigate the need for both effective mixing and linkage learning, two test problems are considered: ORDER problem ...
Ondas, Radovan   +2 more
core   +2 more sources

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