Results 201 to 210 of about 324,903 (264)

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Genetic and Respiratory Pathogenic Comparison of Two PRRSV-2 Isolates Classified as Lineage Korean A and B. [PDF]

Transbound Emerg Dis
Na H, Chae C.
europepmc   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo. [PDF]

Elife
Shi M, Li J, Liu X, Liu K, He L, Pu W, Weng W, Zhang S, Zhao H, Lui K, Zhou B.   +10 more
europepmc   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Genomic characterization and recombination analysis of hepatitis E virus in humans and swine across Asia: implications for food safety. [PDF]

Front Microbiol
Liu D, He Z, Luo Q, Liu B, Zhang P, Chen J, Wang X, Wang G, Huang Y, Xiang H, Cai R.   +10 more
europepmc   +1 more source

Genomic and patient epidemiology of <i>Streptococcus dysgalactiae</i> subspecies <i>equisimilis</i> in Houston, Texas. [PDF]

Microbiol Spectr
Pouga L, Beres SB, Olsen RJ, Long SW, Graviss EA, Musser JM.   +5 more
europepmc   +1 more source

Screening of microhaplotypes for paternity testing from low-recombination regions in the human genome. [PDF]

BMC Genomics
Cang J, Cong R, Du Z, Wu R, Zha L, Liu G.   +5 more
europepmc   +1 more source

Recombination landscape shaped by inversion polymorphisms: a high-density linkage map and chromosome-level assembly of inversion-rich spruce bark beetle genome. [PDF]

G3 (Bethesda)
Nadachowska-Brzyska K, Maryańska-Nadachowska A, Kandasamy D, Andersson MN, Nowak Z, Zieliński P, Rodriguez M, Babik W.   +7 more
europepmc   +1 more source