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Genetic Engineering Using Homologous Recombination
Annual Review of Genetics, 2002▪ Abstract In the past few years, in vivo technologies have emerged that, due to their efficiency and simplicity, may one day replace standard genetic engineering techniques. Constructs can be made on plasmids or directly on the Escherichia coli chromosome from PCR products or synthetic oligonucleotides by homologous recombination.
Donald L, Court +2 more
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Recombinant proteins for genetic disease
Clinical Genetics, 1999The era of molecular biology has led to the development of powerful tools capable of generating therapeutics for genetic disorders. Although there is much current emphasis placed on the development of ‘gene therapy’ for human disease, developments in the production and availability of recombinant proteins are likely to have a more substantial impact on
C S, Russell, L A, Clarke
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Models of Genetic Recombination
Annual Review of Microbiology, 1974It will be my intention to compare established and recently proposed models for . genetic recombination, with special attention to the separate component principles they contain and the function ofthese principles in the various models. As increasing attention has been paid to realistic details of DNA structure and enzymology, recombination models have
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Recombineering: Genetic Engineering in Bacteria Using Homologous Recombination
Current Protocols in Molecular Biology, 2014AbstractThe bacterial chromosome and bacterial plasmids can be engineered in vivo by homologous recombination using PCR products and synthetic oligonucleotides as substrates. This is possible because bacteriophage‐encoded recombination proteins efficiently recombine sequences with homologies as short as 35 to 50 bases.
Lynn C, Thomason +4 more
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Genetic Recombination in Bacteriophage
1965Publisher Summary This chapter discusses the genetic recombination in bacteriophage. Although many aspects of the biochemistry, genetics, and general physiology of the system are pertinent to the question of recombination in bacteriophages, the chapter considers only certain facets of the problem. Specifically, the idea of some kind of phosphodiester
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Group representation of genetic recombinations
The Bulletin of Mathematical Biophysics, 1964An algebraic representation of operations of genetic recombinations is illustrated. It is shown that the recombinations between chromosomes in the two-strand model can be represented by groups, in the sense of the theory of groups. Recombinations between chromosomes with inversions and a translocation are considered as well as cases without them. It is
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Detecting and Analyzing Genetic Recombination Using RDP4.
Methods in molecular biology, 2017D. Martin +3 more
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Genetic control of intrachromosomal recombination
BioEssays, 1995AbstractIntrachromosomal recombination between direct repeats can occur either as gene conversion events, which maintain exactly the number of repeat units, or as deletions, which reduce the number of repeat units. Gene conversions are classical recombination events that utilize the standard chromosome recombination machinery.
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1993
The application of genetic algorithms to optimisation problems for which the solution is a set or multiset (bag) is considered. A previous extension of schema analysis, known as forma analysis, is further developed and used to construct principled representations and operators for problems in this class.
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The application of genetic algorithms to optimisation problems for which the solution is a set or multiset (bag) is considered. A previous extension of schema analysis, known as forma analysis, is further developed and used to construct principled representations and operators for problems in this class.
openaire +1 more source