Results 141 to 150 of about 8,942,317 (309)

Severity of Cognitive Deficits, Disability, and Apolipoprotein E Gene Polymorphisms in Dementia: A Hospital Based Cross-Sectional Study of Predominant Rural Patients

Journal of Psychiatry Spectrum
Background: Late-onset Alzheimer’s disease causes progressive cognitive decline and functional impairment, with the Apolipoprotein E (APOE) ε4 allele as its major genetic risk factor.
Karmachandran Maniamma Nandhu, Srinivas Kosgi, Vaishali Narayana Hegde, Vijaykumar Yenagi, Shivarudrappa R. Bhairappanavar   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Communicating genetic risk

, 2017
The discovery of cancer predisposing genetic mutations has heightened community awareness of the link between family history, genetic constitution, and personal risk.
Elizabeth Lobb, Clara Gaff, Louise Keogh
core   +1 more source

An exploratory exome-wide machine learning analysis identifies candidate host gene signatures associated with Long COVID in a large admixed Brazilian cohort

Frontiers in Medicine
IntroductionGenetic factors have been suggested as modifiers of vulnerability to postCOVID-19 sequelae, referred to as Long COVID (LC). We hypothesize that LC may involve central nervous system (CNS)-related mechanisms, influenced by neuroinflammatory ...
Aléxia Stefani Siqueira Zetum, Danielle Ribeiro Campos da Silva, Danielle Ribeiro Campos da Silva, Vinícius Do Prado Ventorim, Felipe Ataides Mion, Felipe dos Santos Passarela, Henrique Perini Rosa, Túlio de Lima Campos, Bartolomeu Acioli-Santos, Flávio Rosendo da Silva Oliveira, Karen Ruth Michio Barbosa, Livia Cesar Morais, Raquel Silva dos Reis Trabach, Lorena Souza Castro Altoé, Yasmin Moreto Guaitolini, Patrícia Brasil, Matheus Correia Casotti, Iúri Drumond Louro, Débora Dummer Meira   +18 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A new direction for farm animal genetic resources [PDF]

, 2009
In September 2007, the International Technical Conference on Animal Genetic Resources for Food and Agriculture was held in Interlaken, Switzerland. Two important documents aiming at preventing the genetic erosion of farm animal biodiversity and promoting
Kantanen, Juha
core  

Recent Enhancements to the Genetic Risk Prediction Model BRCAPRO

, 2015
BRCAPRO is a widely used model for genetic risk prediction of breast cancer. It is a function within the R package BayesMendel and is used to calculate the probabilities of being a carrier of a deleterious mutation in one or both of the BRCA genes, as ...
Swati Biswas, Amanda Blackford, Emanuele Mazzola, Giovanni Parmigiani   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis

Frontiers in Immunology
IntroductionAsthma is a heterogeneous condition that is characterized by reversible airway obstruction. Childhood-onset asthma (COA) and adult-onset asthma (AOA) are two prominent asthma subtypes, each with unique etiological factors and prognosis, which
Roan E. Zaied, Sreemol Gokuladhas, Caroline Walker, Justin M. O’Sullivan, Justin M. O’Sullivan, Justin M. O’Sullivan, Justin M. O’Sullivan, Justin M. O’Sullivan   +7 more
doaj   +1 more source