Results 201 to 210 of about 8,942,317 (309)

Clinical Utility of a Type 1 Diabetes Genetic Risk Score Measured as Part of MODY Genetic Testing. [PDF]

Diabetes Care
Murray Leech J, Sriram A, Colclough K, Hattersley AT, Houghton JAL, Laver TW, Patel KA.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A Genetic Risk Variant Associated With the Risk of Primary Biliary Cholangitis Is Inherited From Neanderthals. [PDF]

Liver Int
Gerussi A, Caime C, Wang H, Cordell HJ, Mells GF, Sandford RN, Jones DE, Hirschfield G, Siminovitch KA, Gershwin ME, Juran BD, Atkinson EJ, Cheung A, Andrade M, Baras A, Lazaridis KN, Asselta R, Invernizzi P, Sironi M, Sankararaman S, Canadian‐US PBC Consortium, UK‐PBC Consortium, Italian PBC Genetics Study Group.   +22 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Hereditary Pancreatic Cancer: Genetic Risk, Surveillance Strategies, and Therapeutic Implications. [PDF]

Int J Mol Sci
Marafioti M, Patruno M, Musarra M, Silvestris N, Portillo Funes JA, Omero F, Sapuppo E, Cianci V, Calabrò M, Irrera N, Briuglia S, Santarpia M, Speranza D.   +12 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Genetic Risk Architecture of Late-Onset Alzheimer's Disease: Mapping Single-Nucleotide Polymorphisms to Disease-Defining Molecular Pathways. [PDF]

Life (Basel)
Matei C, Palade NA, Dobri-Nicoara AM, Dumitriu DO, Mutu C, Popescu ASC, Pintea AL, Atasie D.   +7 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

A direct-from-serum method for calculating a type 1 diabetes genetic risk score. [PDF]

J Transl Med
Spurrier B, Oram RA, Thomas NJ, Locke JM.   +3 more
europepmc   +1 more source