Results 241 to 250 of about 8,942,317 (309)

Translating Osteoarthritis Genetic Risk Into Biomarkers: Opportunities, Pitfalls, and Implementation Considerations. [PDF]

Hum Mutat
Meng T, Ma L, Zhang X, Han J, Li F, Wu W, Liu S, Liu A.   +7 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Considering social risk alongside genetic risk for bipolar disorder in the All of Us Research Program. [PDF]

HGG Adv
Sharp RR, Hysong MR, Mealer RG, Raffield LM, Glover L, Love MI.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Association of genetic risk and physical activity with incident type 2 diabetes.

J Clin Endocrinol Metab
Zhou X, Carrasquilla GD, Christiansen MR, Smit RAJ, Ängquist L, Hansen T, Loos RJF, Grarup N, Linneberg A, Kilpeläinen TO, Merino J.   +10 more
europepmc   +1 more source

Locus-specific stratification and prioritization unveil genetic risk mechanism underlying complex diseases. [PDF]

Nat Commun
Zhang J, Liu Q, Zhu Y, Xia L, Wang K, Guo Y, Gong L, Liu Z, Qin Z, Shi S, Yang J.   +10 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Toxicity related to immunotherapy in urothelial cancer: Tumour genetic risk variants. [PDF]

Pharmacogenomics J
Rodríguez-Piñas JM, Romero-Lorca A, Novillo A, Gaibar M, Rubio M, Antón-Pascual B, Hernando S, Alemany I, Camacho FI, Cavanagh M, Boiza M, Marrupe D, Martín AM, Khedaoui R, Fernández-Santander A.   +14 more
europepmc   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Associations Between Domestic Water Hardness, Genetic Risk and Severe MASLD: A Large-Scale Cohort Study. [PDF]

FASEB J
Zhao X, Gui Z, He H, Yang M, Lin Y, Shen J, Wang N, Wan H, Tian F.   +8 more
europepmc   +1 more source