Results 161 to 170 of about 445,590 (261)

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study. [PDF]

BJOG
Tristani-Firouzi B, Pappas L, Joseph M, Zeinomar M, Debbink MP, Mims J, Guerrero R, Moore B, Silver RM, Workalemahu T, Haas D, Steller JG, Saade G, Blue NR.   +13 more
europepmc   +1 more source

The Value of Genetic Risk Scores to Predict Hypertension

The Journal of Clinical Hypertension, 2015
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Applying Genetic Risk Score to Improve Risk Assessment of New-Onset Lupus Nephritis in Systemic Lupus Erythematosus: A Large-Scale Prospective Cohort Study. [PDF]

MedComm (2020)
Ding Y, Li M, Bai W, Qian J, Cao M, Xu J, Duan X, Luo H, Zhao C, Zhan F, Yang M, Wu R, Wu L, Chen Z, Wei W, Xu Y, Zhang S, Leng X, Wang Q, Tian X, Gao P, Zeng X, Yang X, Li M, Zhao J.   +24 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Association Between a Multi-Locus Genetic Risk Score and Inflammatory Bowel Disease

Bioinformatics and Biology Insights, 2013
Pingzhao Hu, Aleixo M. Muise, Xiang Xing, John H. Brumell, Mark S. Silverberg, Wei Xu   +5 more
doaj  

Predictability of genetic risk score for insulin resistance is influenced by both BMI and race. [PDF]

Obesity (Silver Spring)
Yurchishin ML, Fowler LA, Goss AM, Garvey WT, Gower BA.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Utility of type 1 diabetes genetic risk score in a non-European population: insights from an Iranian cohort. [PDF]

Diabetol Metab Syndr
Moazzam-Jazi M, Asgarian S, Hadaegh F, Momenan A, Mahmoudieh L, Najd Hassan-Bonab L, Masjoudi S, Zahedi A, Lanjanian H, Akbarzadeh M, Hedayati M, Alfadhli S, Azizi F, Daneshpour MS.   +13 more
europepmc   +1 more source