Results 61 to 70 of about 5,319,582 (307)

Environmental coupling of selection and heritability limits evolution [PDF]

, 2006
There has recently been great interest in applying theoretical quantitative genetic models to empirical studies of evolution in wild populations. However, while classical models assume environmental constancy, most natural populations exist in variable ...
T H Clutton-Brock, D W Coltman, Pemberton J. M, Coltman, D. W., J. G. Pilkington, A. J. Wilson, Pemberton, J. M., D. W. Coltman, J G Pilkington, L E B Kruuk, Mifsud, D. V., Coltman D. W, J. M. Pemberton, D V Mifsud, D. V. Mifsud, Clutton-Brock T. H, Pilkington, J. G., Pilkington J. G, Wilson, A. J., Kruuk, L. E. B., A J Wilson, L. E. B. Kruuk, Clutton-Brock, T. H., T. H. Clutton-brock, Wilson A. J, Mifsud D. V, Kruuk L. E. B, J M Pemberton   +27 more
core   +2 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Spatiotemporal patterns of genetic variation for growth and fertility in Scots pine [PDF]

, 2011
Genetic testing plays an important role in tree breeding. Understanding basic genetic parameters for growth and fertility is a prerequisite for developing a successful breeding strategy to balance between short- and long-term gains.
Kroon, Johan
core   +1 more source

A new genetic algorithm for multi-label correlation-based feature selection. [PDF]

, 2015
This paper proposes a new Genetic Algorithm for Multi-Label Correlation-Based Feature Selection (GA-ML-CFS). This GA performs a global search in the space of candidate feature subset, in order to select a high-quality feature subset is used by a multi ...
Jungjit, Suwimol, Freitas, Alex A.
core   +1 more source

Genetic correlations among protein yield, productive life, and type traits from the United States and diseases other than mastitis from Denmark and Sweden [PDF]

, 1999
Sire genetic evaluations for protein yield, productive life, and selected type traits from the US were correlated with sire evaluations for disease from Denmark and Sweden and were then adjusted to approximate genetic correlations.
Banos, G, Rogers, GW, Sander-Nielsen, U, G. Banos, G.W. Rogers, U. Sander-Nielsen   +5 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Genetics Select

Cell, 2008
The complete human genome sequence presents researchers with unique opportunities not only for identifying the mechanisms underlying a battery of genetic diseases but also for revealing what makes us human. This issue's Genetics Select highlights recent developments in the field of human genetics that promise to direct future studies in the fields of ...
openaire   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Potential benefit from using an identified major gene in BLUP evaluation with truncation and optimal selection [PDF]

, 1999
This study investigates the benefit of including information on an identified major gene in the estimation of breeding values in BLUP selection programmes. Selection for a quantitative trait is controlled by polygenes and a major locus with known effect.
Ricardo Pong-Wong, Grundy, B, Woolliams, JA, Villanueva, B., Pong-Wong, R.; id_orcid, Beatriz Villanueva, Villanueva, B, Pong-Wong, R, John A. Woolliams, Grundy, B., Woolliams, John, Brian Grundy, Woolliams John A, John A Woolliams, Grundy Brian, Villanueva Beatriz, Pong-Wong Ricardo   +16 more
core   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source