Results 161 to 170 of about 828,986 (313)
Fuzzy clustering of univariate and multivariate time series by genetic multiobjective optimization [PDF]
Given a set of time series, it is of interest to discover subsets that share similar properties. For instance, this may be useful for identifying and estimating a single model that may fit conveniently several time series, instead of performing the usual
S. Bandyopadhyay, R. Baragona, U. Maulik
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Will New Genetic Techniques Like Exome Sequencing and Others Obviate the Need for Clinical Expertise? Yes. [PDF]
Mov Disord Clin Pract, 2017 Bonifati V.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular genetic techniques for gene manipulation in Candida albicans. [PDF]
Virulence, 2014 Xu QR +6 more
europepmc +1 more source
Genetic Algorithm Assisted Adaptive Beamforming
, 2002 Genetic Algorithm (GA) assisted beamforming techniques are proposed as an alternative to conventional beamforming algorithms. The design of the corresponding GAs is highlighted and the achievable performance is characterised in terms of the Signal-to ...
Ahmad, N.N. +3 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Developing Next-Generation Live Attenuated Vaccines for Porcine Epidemic Diarrhea Using Reverse Genetic Techniques. [PDF]
Vaccines (Basel)Yu R, Dong S, Chen B, Si F, Li C.
europepmc +1 more source
, 1997 This status report describes the existing techniques for in vitro conservation of plant cells, tissues and organs, their current state of the art, present application and existing problems, identifies priority areas for collaborative research, technology
Ashmore, Sarah E.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source