Results 261 to 270 of about 1,750,857 (329)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Multi-omics research on moyamoya disease: current perspectives and future directions. [PDF]

Nutr Metab (Lond)
Guo Q, Li N.
europepmc   +1 more source

Study of genetic variation in Staphylococcus aureus strains isolated from clinical specimens by RAPD-PCR Technique

, 2020
Baroomand Morvaridi, Shahram Nakhjavan, Shahram Nanekarani, Reza Yari   +3 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Endometrial Hyperplasia: Current Insights into Epidemiology, Risk Factors, and Clinical Management. [PDF]

Cancers (Basel)
Galani A, Stavros S, Moustakli E, Potiris A, Zikopoulos A, Anagnostaki I, Zacharis K, Paraskevaidi M, Lyons D, Maneta-Stavrakaki S, Thomakos N, Kyrgiou M, Domali E.   +12 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Rethinking gene-edited crop regulation: advancing a Principle-based framework for modern biotechnology governance. [PDF]

GM Crops Food
Vengadesen S, Bin Abdul Aziz MF, Jones MK.   +2 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Integrative Sequencing and Proteogenomic Approaches to Intratumoral Heterogeneity in Cholangiocarcinoma: Implications for Precision Diagnosis and Therapy. [PDF]

Med Sci (Basel)
Sitthirak S, Wangwiwatsin A, Jusakul A, Namwat N, Klanrit P, Roytrakul S, Dokduang H, Duangchan T, Rattanapan Y, Titapun A, Jareanrat A, Thanasukarn V, Khuntikeo N, Tean TB, Boulter L, Murakami Y, Loilome W.   +16 more
europepmc   +1 more source

Application of genetic algorithm in the parameter configuration techniques for load balancing WSN

, 2017
Matheus Lorenzato Braga
openalex   +1 more source