Results 191 to 200 of about 951,804 (263)

Exploring the Effect of Genetic Testing on Personalised Treatment Plans for Depression. [PDF]

Actas Esp Psiquiatr
Li S, Peng L, Wang Y.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Proposed North American Approach for Genetic Testing of Individuals at Risk for Malignant Hyperthermia. [PDF]

Anesthesiology
Riazi S, Watt S, Plester J, Biesecker LG.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Genetic Testing for APOL1 in Adults With Hypertension: The GUARDD-US Randomized Clinical Trial.

JAMA Netw Open
Eadon MT, Cavanaugh KL, She L, Steen-Burrell KA, Mohottige D, Nadkarni GN, Kitzman H, Chakraborty H, Empey PE, Limdi NA, Singh R, Beasley CM, Parker AS, Cicali EJ, Ramos MA, Clermont S, Dodgen L, Elwood EN, Robinson M, Umeukeje EM, Garcia Ortega A, Shroff N, Rosenman MB, Nguyen KA, Volpi S, Rider R, Dexter PR, Skaar TC, Peterson JF, Cavallari LH, Johnson JA, Wyatt CM, Orlando LA, Cooper-DeHoff RM, Horowitz CR, Implementing Genomics in Practice (IGNITE) Pragmatic Trials Network.   +35 more
europepmc   +1 more source

A survey of factors influencing the intention to undergo genetic testing in patients with cardiovascular disease in Japan. [PDF]

J Genet Couns
Miyoshi T, Mizuno A, Watanabe M, Isa K, Fujita K, Kubo T, Nomura S.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Retraction: Genetic Testing for Successful Cancer Treatment. [PDF]

Cureus
Singh DN, Daripelli S, Elamin Bushara MO, Polevoy GG, Prasanna M.   +4 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patterns of X-Linked Retinitis Pigmentosa Genetic Testing in England and Implications for Service Provision. [PDF]

Ophthalmol Sci
Yates S, Whittaker W, Harrison M, Bayliss S, Barton S, Sergouniotis PI, Payne K, Black G.   +7 more
europepmc   +1 more source