Results 281 to 290 of about 1,824,368 (348)

External quality assessment of genetic testing for hereditary hearing loss in Shanghai and other regions. [PDF]

Pract Lab Med
Bao Y, Zhang P, Quan J, Yang X, Xiao Y, Hu X.   +5 more
europepmc   +1 more source

Analysis of Standardized Achievement Tests by Classical Test Theory and Genetic Factor Analysis Models

, 1998
Yukimasa Muraishi, Hideki Toyoda
openalex   +2 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Application of Genetic Testing for Anorexia Nervosa: An Ethical Analysis. [PDF]

Brain Behav
Ramsay S, Allison K, Temples HS, Sarasua S, Boccuto L.   +4 more
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Deciding on genetic testing for familial dementia: Perspectives of patients and families. [PDF]

Alzheimers Dement
van der Schaar J, van der Lee SJ, Asscher ECA, Pijnenburg YAL, de Geus CM, Bredenoord AL, van der Flier WM, van den Hoven MA, Smets EMA, Visser LNC.   +9 more
europepmc   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Canadian Recommendations for Germline Genetic Testing of Patients with Breast Cancer: A Call to Action. [PDF]

Curr Oncol
Weber E, Carmona-Gonzalez CA, Boucher M, Eisen A, Laing K, Melvin J, Schrader KA, Sehdev S, Wong SM, Gelmon KA.   +9 more
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Multidisciplinary stakeholder-informed identification of key characteristics for implementation of workplace genetic testing. [PDF]

HGG Adv
Charnysh E, Sanghavi K, Ryan KA, Vogle A, Truhlar A, Pal S, Reader JM, Roberts JS, Lee C, Prince AER, Feero WG, INSIGHT @ Work Consortium.   +11 more
europepmc   +1 more source