Results 301 to 310 of about 1,824,368 (348)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Pediatric predictive testing to inform preimplantation genetic testing: A case report and review of the literature. [PDF]

J Genet Couns
Schaa KL, Thoeny R, Benson RJ, Pitcher GJ, Romoser S, Sidhu A.   +5 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Yield of Genetic Testing in Children with Autism Spectrum Disorder - A Single-Center Experience. [PDF]

Ann Indian Acad Neurol
Arora K, Balwani M, Wakchaure A, Passi GR.   +3 more
europepmc   +1 more source

Knowledge, attitude, and practice toward genetic testing in breast cancer patients in China. [PDF]

PLoS One
Ye X, Xu T, Cao J, Li G, Zhuang M, Hu G, Chen H, Wang M, Wang J.   +8 more
europepmc   +1 more source

Preimplantation Genetic Testing for Aneuploidy in Recurrent Pregnancy Loss: A Fertility Success Story. [PDF]

Cureus
Ziogas AC, Liasidi PN, Katouna A, Koutsouni A, Faki K, Karangeli E, Thanasa E, Thanasa A, Thanasas I, Xydias EM.   +9 more
europepmc   +1 more source

Genetic Testing in Hyperlipidemia [PDF]

Endocrinology and Metabolism Clinics of North America, 2015
Hereditary dyslipidemias are often underdiagnosed and undertreated, yet with significant health implications, most importantly causing preventable premature cardiovascular diseases. The commonly used clinical criteria to diagnose hereditary lipid disorders are specific but are not very sensitive.
Christie M. Ballantyne, Yashashwi Pokharel, Ozlem Bilen   +2 more
openaire   +4 more sources