Results 321 to 330 of about 17,080,653 (424)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Healthcare delay in neurogenetic disorders of adult onset and the role of predictive genetic testing. [PDF]

J Community Genet
Rocha DL, Pinheiro JDS, Furtado GV, Kowalski TW, Donis KC, Chaves M, Chini G, Monte TL, de Castilhos RM, Saraiva-Pereira ML, Schuler-Faccini L, Jardim LB.   +11 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Cross-border genetic testing

Orphanet Journal of Rare Diseases, 2010
Barton David
doaj   +1 more source

An exploration of delegation practices regarding the utilization of genetic counseling assistants for disclosure of genetic testing results. [PDF]

J Genet Couns
Ranson D, Allison CO, Wetherill L, Delk PR, Stone K.   +4 more
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Application of third-generation sequencing technology in the genetic testing of thalassemia. [PDF]

Mol Cytogenet
Li W, Ye Y.
europepmc   +1 more source

Application of genetic testing criteria for hereditary breast cancer in South Africa. [PDF]

Breast Cancer Res Treat
Osler TS, Schoeman M, Pretorius WJS, Mathew CG, Edge J, Urban MF.   +5 more
europepmc   +1 more source

Responsibility of genetic testing [PDF]

Genetics in Medicine, 2004
openaire   +2 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source