Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Estimates of genetic parameters, genetic trends, and inbreeding in a crossbred dairy sheep research flock in the United States1 [PDF]
, 2017 Thomas W Murphy +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Genetic Parameters, Breeding Values and Genetic Trends for Some Productive and Reproductive Traits of Holstein Cows in Egypt [PDF]
, 2019 Tamer M. Abdel-Hamid +3 more
openalex +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Macrogenetics Approach Reveals Spatial Trends and Drivers of Mitochondrial Genetic Diversity at Different Biological Organization Levels in Tropical Western Atlantic Decapods [PDF]
Pedro A. Peres +1 more
openalex +1 more source
Genetic Trend and Relationship of Meatiness Traits of Different Breed Pigs Raised in Lithuania [PDF]
, 2009 Ramutis Klimas, A. Klimienė
openalex +1 more source
Trends in genetics--before the molecular era.
Hereditas, 2010 Molecular techniques and biochemical questions came to dominate genetic research during the later half of the 1900th century. This does not mean that earlier achievements have lost their importance. In this review the trends in classic genetics are followed from the beginning in 1900 until the molecular aspects took over, and it is shown how they form ...
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source