Results 191 to 200 of about 1,104,984 (330)

Association of <i>MMP9</i> and <i>NOS3</i> Polymorphisms with Distinct Clinical Forms of Juvenile Scleroderma and Characteristics of Humoral Immunity. [PDF]

Int J Mol Sci
Osminina M, Podzolkova V, Litvinova M, Geppe N, Chebysheva S, Khachatryan L, Golovanova N, Kostina Y, Lazareva-Batyreva O, Polyanskaya A, Shpitonkova O, Subbotina T, Areian T, Podchernyaeva N.   +13 more
europepmc   +1 more source

Estimation of Breeding Values and Genetic Trend of Production Traits in Munjal Sheep

, 2018
Umeel Yadav, Zile Malik, Devender Singh Dalal, S. P. Dahiya, Chandrashekhar S. Patil   +4 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Estimation of Genetic Parameters and Genetic Trends of Somatic Cell Score in Iranian Holstein Cows Using Test Day Records

, 2014
K H Pirali Kheirabadi, S. Alijani
openalex   +1 more source

Genetic parameters and trends of cow livability in Holsteins in Hokkaido, Japan

, 2020
H. Abe, Koichi HAGIYA, Satoshi Yamaguchi, Satoshi Nakagawa, Yusaku GOTOH, Toshimi Baba, Takayoshi Kawahara   +6 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Space-time distribution of classical scrapie in Italian sheep: assessing the effectiveness of the National Genetic Selection Plan. [PDF]

Vet Res
Desiato R, Ingravalle F, Bertolini S, Aiassa E, Barzanti P, Perrotta MG, Catelan D, Ru G.   +7 more
europepmc   +1 more source

Genetic Parameters and Annual Trends for Birth and Weaning Weights of a Northeastern Thai Indigenous Cattle Line [PDF]

, 2008
W. Intaratham, Skorn Koonawootrittriron, Panwadee Sopannarath, HU Graser, Sornthep Tumwasorn   +4 more
openalex   +1 more source

Genetic parameter and genetic trend estimates for reproductive traits in Wistar rats [PDF]

, 2020
Graziela Tarôco, José Teodoro de Paiva, Gérson Barreto Mourão, José Bento Sterman Ferraz, E. C. Mattos, Joanir Pereira Eler, Daniela Regina Resende, Leila de Genova Gaya   +7 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source