Results 231 to 240 of about 3,562,262 (302)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Consistent and idiosyncratic pleiotropy in shaping genetic correlations. [PDF]

Mol Biol Evol
Cai H, Geiler-Samerotte K, Des Marais DL.   +2 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Recent trends in Early-Onset cancer incidence rates. [PDF]

J Natl Cancer Inst
Hong YD, Chen HS, Liu B, Noone AM, Stout NK, Mariotto AB, Cronin KA.   +6 more
europepmc   +1 more source

Annual report / Genetic Systems Corporation. 1982

, 2013
Genetic Systems Corporation
core  

Genetic Sequencing in Saudi Patients with Systemic Lupus Erythematosus. [PDF]

Open Access Rheumatol
Al-Homood IA, Binhassan S, AlMatham K, Hassen LM, Samman M.   +4 more
europepmc   +1 more source

Genetic Associations of Functional Longevity With Sexual Precocity and Growth Traits in Nellore Beef Cattle. [PDF]

J Anim Breed Genet
Dos Santos DR, de Souza Silva Fernandes G, Boligon AA, Santana ML, de Oliveira Menezes GR, Ayres DR, Bignardi AB, Pereira RJ.   +7 more
europepmc   +1 more source

Integrated Genetic Risk Stratification Identifies High Adenoma Detection Rates at Colonoscopy in a Real-World US Health System. [PDF]

Gastro Hep Adv
Zolotarevsky MV, Karimabady K, Muhammad R, Ashworth A, Mulford A, Shi Z, Tran H, Wei J, Zheng SL, Helfand BT, Sanders AR, Ross A, Jones B, Xu J.   +13 more
europepmc   +1 more source

Research note: Genetic background influences the relationship between age at first egg and long-term egg production in layers. [PDF]

Poult Sci
Ni A, Calus MPL, Bovenhuis H, Li Y, Yuan J, Sun Y, Chen J.   +6 more
europepmc   +1 more source

Cross-Sectional and Prospective Associations of Carbonated Soft Drink Consumption, <i>BDNF</i> Val66Met Polymorphism, and Psychological Distress. [PDF]

Nutrients
Baik I.
europepmc   +1 more source