Results 31 to 40 of about 4,243,841 (306)

Genetics and Variable Drug Response [PDF]

JAMA, 2011
Annual health care expenditures currently exceed $2.5 trillion in the United States, a cost burden equivalent to more than $8000 per person per year. Treatment strategies designed to optimize efficacy, ie, avoiding therapeutic failure while minimizing toxicity, hold the potential to reduce this cost burden.
Russell A, Wilke, M Eileen, Dolan
openaire   +2 more sources

Genetic Variables That Influence Phenotype [PDF]

ILAR Journal, 2006
Characterization of genetically engineered mice requires consideration of the gene of interest and the genetic background on which the mutation is maintained. A fundamental prerequisite to deciphering the genetic factors that influence the phenotype of a mutant mouse is an understanding of genetic nomenclature.
openaire   +2 more sources

Genetic Variability in the Deep Sea: Relation to Environmental Variability [PDF]

Evolution, 1972
A current concept of population biology holds that much genetic variability is maintained in populations as an adaptation tc environmental heterogeneity in time and space (Battaglia, 1963; Bretsky and Lorenz, 1971; Burns and Johnson, 1971; Powell, 1971). Environmental heterogeneity is thought to promote genetic variability by mechanisms of diversifying
James L, Goocii, Thomas J M, Schopf
openaire   +2 more sources

Global amphibian declines, loss of genetic diversity and fitness: a review [PDF]

, 2010
It is well established that a decrease in genetic variation can lead to reduced fitness and lack of adaptability to a changing environment. Amphibians are declining on a global scale, and we present a four-point argument as to why this taxonomic group ...
Allentoft, M.E., John O’Brien, O’Brien, J., Morten Allentoft, Morten E. Allentoft   +4 more
core   +1 more source

Genetic variability and correlation studies in black-gram [Vigna mungo (L.) Hepper]

Electronic Journal of Plant Breeding, 2018
The present investigation was carried out to estimate the genetic variability and genotypic correlation among one hundred and twenty black-gram genotypes for nine quantitative characters.
L. Priya, M. Arumugam Pillai, D. Shoba, S. Merina Perm Kumari and, N. Aananthi   +4 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Evaluation of genetic variability and distances among five Iranian native chicken populations using RAPD markers [PDF]

, 2009
Genetic variability was studied on five Iranian native chicken populations using Random Amplified Polymorphism DNA (RAPD) markers. The purpose of this study was for the analysis of variation within and between Iranian native chicken populations and for ...
Ghorbani, A, Mirhoseini, Seyed Z, Dehghanzadeh, H, Romanov, Michael N, S.Z. Mirhoseini, M.N. Romanov, A. Ghorbani, H. Dehghanzad   +7 more
core   +1 more source

Genetic Variability Under the Seedbank Coalescent [PDF]

Genetics, 2015
Abstract We analyze patterns of genetic variability of populations in the presence of a large seedbank with the help of a new coalescent structure called the seedbank coalescent. This ancestral process appears naturally as a scaling limit of the genealogy of large populations that sustain seedbanks, if the seedbank size and individual
Blath, Jochen, González Casanova, Adrián, Eldon, Bjarki, Kurt, Noemi, Wilke-Berenguer, Maite   +4 more
openaire   +4 more sources

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Multilocus patterns of nucleotide variability and the demographic and selection history of drosophila melanogaster populations [PDF]

, 2005
Uncertainty about the demographic history of populations can hamper genome-wide scans for selection based on population genetic models. To obtain a portrait of the effects of demographic history on genome variability patterns in Drosophila melanogaster ...
Haddrill, Penelope R, Charlesworth, B, Haddrill, P R, Charlesworth, Brian, Thornton, K R, Thornton, Kevin R, Andolfatto, Peter, Andolfatto, P   +7 more
core   +4 more sources