Results 101 to 110 of about 613,182 (293)

Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures. [PDF]

G3 (Bethesda), 2023
Feldmann MJ, Covarrubias-Pazaran G, Piepho HP.   +2 more
europepmc   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

The influence of animals from embryo transfer on the genetic evaluation of growth in Simmental beef cattle by using multi-trait models. [PDF]

, 2015
The weight records from Simmental beef cattle were used in a genetic evaluation of growth with or without the inclusion of animals obtained by embryo transfer. A multi-trait model in which embryo transfer individuals were excluded (MTM1) contained 29,510
LOPES, P. S., MARQUES, L. F. A., MOTA, R. R., RESENDE, M. D. V. de, SILVA, L. P. da, TORRES, R. de A.   +5 more
core  

Genetic parameters for animal mortality in pasture-based, seasonal-calving dairy and beef herds [PDF]

, 2018
peer-reviewedIn the absence of informative health and welfare phenotypes, breeding for reduced animal mortality could improve overall health and welfare, provided genetic variability in animal mortality exists.
Berry, Donagh, Doherty, Michael L., Evans, R. D., Ring, Siobhan C.   +3 more
core   +1 more source

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Equivalence of variance components between standard and recursive genetic models using LDL′ transformations

Genetics Selection Evolution
Background Recursive models are a category of structural equation models that propose a causal relationship between traits. These models are more parameterized than multiple trait models, and they require imposing restrictions on the parameter space to ...
Luis Varona, David López-Carbonell, Houssemeddine Srihi, Carlos Hervás-Rivero, Óscar González-Recio, Juan Altarriba   +5 more
doaj   +1 more source

Evaluating gene by sex and age interactions on cardiovascular risk factors in Brazilian families

BMC Medical Genetics, 2010
Background In family studies, it is important to evaluate the impact of genes and environmental factors on traits of interest. In particular, the relative influences of both genes and the environment may vary in different strata of the population of ...
Krieger José E, de Andrade Mariza, Pereira Alexandre C, Giolo Suely R, Soler Júlia P   +4 more
doaj   +1 more source

Genomic dissection of maternal, additive and non-additive genetic effects for growth and carcass traits in Nile tilapia

Genetics Selection Evolution, 2020
Background The availability of both pedigree and genomic sources of information for animal breeding and genetics has created new challenges in understanding how they can be best used and interpreted. This study estimated genetic variance components based
Rajesh Joshi, Theo H. E. Meuwissen, John A. Woolliams, Hans M. Gjøen   +3 more
doaj   +1 more source

Estimation of Genetic Parameters for Peak Yield, Yield and Persistency Traits in Murciano-Granadina Goats Using Multi-Traits Models [PDF]

, 2019
This paper studies parameters of a lactation curve such as peak yield (PY) and persistency (P), which do not conform to the usual selection criteria in the Murciano-Granadina (MG) breed, but are considered to be an alternative to benefit animal welfare ...
Barba Capote, C.J., Gómez Carpio, Mayra Mercedes, León Jurado, J.M., Miranda, Judith C., Pieramati, C., Valdés, Jesús   +5 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source