Results 51 to 60 of about 613,182 (293)

Sex-specific genetic effects influence variation in body composition [PDF]

, 2008
Aims/hypothesis: Despite well-known sex differences in body composition it is not known whether sex-specific genetic or environmental effects contribute to these differences.
A Comuzzie, A. G. Uitterlinden, AG Comuzzie, AJ Stunkard, AM Herskind, B. A. Oostra, C Malis, C. M. van Duijn, DB Allison, DG Carey, DS Falconer, F. Rivadeneira, FA Sayed-Tabatabaei, FC Hsu, H. A. P. Pols, JC Wells, JE Wigginton, JL Hopper, JR Harris, K Lange, K Samaras, K Schousboe, K Tambs, L Almasy, L. M. Pardo, LA Weiss, LB Brown, LJ Eaves, LJ Martin, LJ Martin, LM Pardo, M Korkeila, M. C. Zillikens, M. Yazdanpanah, MC Neale, ML Blair, N Vaessen, NY Souren, PM Visscher, RL Santos, SG Self, Y. S. Aulchenko, YM Hur   +42 more
core   +4 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Analysis of conditional genetic effects and variance components in developmental genetics. [PDF]

Genetics, 1995
Abstract A genetic model with additive-dominance effects and genotype x environment interactions is presented for quantitative traits with time-dependent measures. The genetic model for phenotypic means at time t conditional on phenotypic means measured at previous time (t-1) is defined.
openaire   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Two variance component model improves genetic prediction in family data sets [PDF]

The American Journal of Human Genetics, 2015
Abstract Genetic prediction based on either identity by state (IBS) sharing or pedigree information has been investigated extensively using Best Linear Unbiased Prediction (BLUP) methods. Such methods were pioneered in the plant and animal breeding literature and have since been applied to predict human traits with ...
Tucker, George, Loh, Po-Ru, MacLeod, Iona M., Hayes, Ben J., Goddard, Michael E., Berger, Bonnie, Price, Alkes L.   +6 more
openaire   +6 more sources

Genetic Variance Components in Cotton by Generation Mean Analysis

BADEGGI JOURNAL OF AGRICULTURAL RESEARCH AND ENVIRONMENT, 2021
The mode of gene action for the expression of quantitative traits is decided by the predominance of variances due to additive, dominance and epistasis gene effects. In this experiment, involving four F1 crosses (TCH1716 x TCB37, TCH1705-101 x TCB209, KC2 x TCB26 and TSH0250 x DB3) of upland cotton, inheritance of major yield components by Generation ...
A. Isong, A. Balu, A. Ahmed, J. O. Mbe, I. G. Mohammed, C. Isong, N. Vinothini, S. T. Gbadeyan   +7 more
openaire   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Equivalence of multibreed animal models and hierarchical Bayes analysis for maternally influenced traits

Genetics Selection Evolution, 2010
Background It has been argued that multibreed animal models should include a heterogeneous covariance structure. However, the estimation of the (co)variance components is not an easy task, because these parameters can not be factored out from the inverse
Cantet Rodolfo JC, Munilla Leguizamón Sebastián   +1 more
doaj   +1 more source

Genetic parameters for milk mineral content and acidity predicted by mid-infrared spectroscopy in Holstein–Friesian cows [PDF]

, 2015
peer-reviewedThis article was first published in animal, Volume 9, Issue 05, May 2015, pp 775-780 © The Animal Consortium 2015The aim of the present study was to estimate genetic parameters for calcium (Ca), phosphorus (P) and titratable acidity (TA) in ...
Berry, Donagh, Cassandro, M., de Marchi, M., McParland, Sinead, Penasa, M., Toffanin, V.   +5 more
core   +1 more source