Results 201 to 210 of about 4,753,986 (376)

Nomenclature of genetic variants in hemostasis [PDF]

Journal of Thrombosis and Haemostasis, 2011
A C, Goodeve, P H, Reitsma, J H, McVey
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Nucleotide‐binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis† [PDF]

, 2009
Beate Appenrodt, F Grünhage, M Gentemann, L Thyssen, Tilman Sauerbruch, Frank Lammert   +5 more
openalex   +1 more source

The Iberian Roma genetic variant server; population structure, susceptibility to disease and adaptive traits [PDF]

, 2023
Fabiola Mavillard, Javier Pérez-Florido, Francisco Ortuño, Amador Valladares, Miren L. Álvarez-Villegas, Gema Roldán, Rosario Carmona, Manuel Soriano Ferrer, Santiago Susarte, Pilar Fuentes, Daniel López-López, Ana María Núñez-Negrillo, Alejandra Carvajal, Yolanda Blanco Morgado, Daniel Arteaga, Rosa Ufano, Pablo Mir, Juan F. Gamella, Joaquı́n Dopazo, Carmen Paradas, Macarena Cabrera‐Serrano   +20 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes [PDF]

, 2011
Qibin Qi, Tsegaselassie Workalemahu, Cuilin Zhang, Frank B. Hu, Lu Qi   +4 more
openalex   +1 more source

Design of a Companion Bioinformatic Tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants [PDF]

, 2020
Alice Massacci, Eleonora Sperandio, Lorenzo D’Ambrosio, Mariano Maffei, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto, Matteo Pallocca   +7 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

, 2014
Heather A. Hong, Maria Paximadis, Glenda Gray, Louise Kuhn, Caroline T. Tiemessen   +4 more
openalex   +2 more sources

A genetic variant of hypoxia-inducible factor-1α is associated with adverse outcomes in acute kidney injury [PDF]

, 2009
Alexey Y. Kolyada, Hocine Tighiouart, Mary C. Perianayagam, Orfeas Liangos, Nicolaos E. Madias, Bertrand L. Jaber   +5 more
openalex   +1 more source