Results 221 to 230 of about 4,570,575 (370)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Re-sequencing of the casein genes in Swedish Red cattle giving milk with diverse protein profiles and extreme rennet coagulation properties

JDS Communications
Impaired rennet coagulation properties in milk could lead to prolonged processing times and production losses. Heritability for milk coagulation has previously been estimated to be 0.28 to 0.45, indicating that genetic selection can be used to manipulate
Frida Lewerentz, Tytti K. Vanhala, Lene Buhelt Johansen, Marie Paulsson, Maria Glantz, Dirk-Jan de Koning   +5 more
doaj  

Structural flexibility of isozyme variants: genetic variants in Drosophila disguised by cofactor and subunit binding.

, 1978
George B. Johnson
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Comparison of autism domains across thirty rare variant genotypesResearch in context

EBioMedicine
Summary: Background: A number of Neurodevelopmental risk Copy Number Variants (ND-CNVs) and Single Gene Variants (SGVs) are strongly linked to elevated likelihood of autism.
Nabila M.H. Ali, Samuel J.R.A. Chawner, Leila Kushan-Wells, Carrie E. Bearden, Jennifer Gladys Mulle, Rebecca M. Pollak, Raquel E. Gur, Wendy K. Chung, Michael J. Owen, Marianne B.M. van den Bree, Harriet Housby, Irene Lee, David Skuse, Jeanne Wolstencroft, William Mandy, Spiros Denaxas, Kate Baker, Lucy Raymond, Marianne van den Bree, Samuel Chawner, Jeremy Hall, Peter Holmans, Josh Hope-Bell, Danielle Le Roux, Sally Morrin, Michael Owen, Shreeya Sivakumar   +26 more
doaj  

Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.

, 1983
A. Dusty Miller, David I. Israel, James P. Whitlock   +2 more
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review. [PDF]

Neurogenetics
Duarte-Zambrano F, Alfonso-Cedeño DF, Barrero JA, Rodríguez-Vanegas LA, Moreno-Cárdenas V, Olarte-Díaz A, Arboleda G, Arboleda H.   +7 more
europepmc   +1 more source

Behavioral and Cytogenetic Analysis of the cacophony Courtship Song Mutant and Interacting Genetic Variants in Drosophila melanogaster

, 1987
Shankar J. Kulkarni, Jeffrey C. Hall
openalex   +2 more sources