Results 221 to 230 of about 4,615,445 (390)

Comparison of autism domains across thirty rare variant genotypesResearch in context

EBioMedicine
Summary: Background: A number of Neurodevelopmental risk Copy Number Variants (ND-CNVs) and Single Gene Variants (SGVs) are strongly linked to elevated likelihood of autism.
Nabila M.H. Ali, Samuel J.R.A. Chawner, Leila Kushan-Wells, Carrie E. Bearden, Jennifer Gladys Mulle, Rebecca M. Pollak, Raquel E. Gur, Wendy K. Chung, Michael J. Owen, Marianne B.M. van den Bree, Harriet Housby, Irene Lee, David Skuse, Jeanne Wolstencroft, William Mandy, Spiros Denaxas, Kate Baker, Lucy Raymond, Marianne van den Bree, Samuel Chawner, Jeremy Hall, Peter Holmans, Josh Hope-Bell, Danielle Le Roux, Sally Morrin, Michael Owen, Shreeya Sivakumar   +26 more
doaj  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Overview of genetic variants in a cohort of Iranian patients with leukodystrophy. [PDF]

Sci Rep
Fathi M, Khalilian S, Miryounesi M, Ghafouri-Fard S.   +3 more
europepmc   +1 more source

Structural flexibility of isozyme variants: genetic variants in Drosophila disguised by cofactor and subunit binding.

, 1978
George B. Johnson
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Re-sequencing of the casein genes in Swedish Red cattle giving milk with diverse protein profiles and extreme rennet coagulation properties

JDS Communications
Impaired rennet coagulation properties in milk could lead to prolonged processing times and production losses. Heritability for milk coagulation has previously been estimated to be 0.28 to 0.45, indicating that genetic selection can be used to manipulate
Frida Lewerentz, Tytti K. Vanhala, Lene Buhelt Johansen, Marie Paulsson, Maria Glantz, Dirk-Jan de Koning   +5 more
doaj  

Mitochondrial Hearing Loss: Genetic Variants and Clinical Progression. [PDF]

Cureus
Miwa T, Hashimoto K, Seto T, Sakamoto H.
europepmc   +1 more source

Effect of Serial Passage on Genetic Homogeneity of a Plaque Variant of Lymantria dispar Nuclear Polyhedrosis Virus (Hamden LDP-67)

, 1989
Timothy M. Cusack, William J. McCarthy
openalex   +1 more source

Voila, a NewDrosophilaCourtship Variant that Affects the Nervous System: Behavioral, Neural, and Genetic Characterization [PDF]

, 1998
Maria Balakireva, Reinhard F. Stocker, Nanaë Gendre, Jean‐François Ferveur   +3 more
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source