Results 231 to 240 of about 1,189,631 (302)

Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization. [PDF]

Discov Oncol
Li S, Zhang K, Zhang G, Shi M, Yin X, Wang B.   +5 more
europepmc   +1 more source

Electrophoresis for analysis of genetic variants; polymerase chain reaction(PCR), mismatched PCR.

, 1999
Kayoko Sudo, Masato Maekawa
openalex   +2 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Disease-associated genetic variants can cause mutations in tissue-specific protein isoforms

Weykopf G, Badonyi M, Friman ET, Nguyen JMH, Ioannou A, Livesey BJ, Coutts A, Hird EF, Wham M, Stanton CM, Vitart V, Su J, Murphy L, Baillie JK, Gorrell MD, Marsh JA, Bickmore WA, Biddie SC.   +17 more
europepmc   +1 more source

Clinical significance and prognostic value of SIRT1 genetic variants in sepsis: a multicenter hospital-based case-control study. [PDF]

Clin Epigenetics
He J, Yang M, Lin Y, Qin W, Yang R, Qin Y, Liu L, Xu M, Shao Y, Liu Q.   +9 more
europepmc   +1 more source

The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

, 2000
Paul Lyons, Wayne W. Hancock, Paul Denny, Christopher J. Lord, Natasha Hill, N Armitage, Thorsten Siegmund, John A. Todd, Michael Phillips, J. Fred Hess, Shiow-Ling Chen, Paul Fischer, Laurence B. Peterson, Linda S. Wicker   +13 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Association of CD33 genetic variants with neurocognitive profiles in chronic viral hepatitis. [PDF]

BJPsych Open
Tsai WF, Yu RL, Chuang WL, Huang JF, Dai CY, Huang YA, Tan CH.   +6 more
europepmc   +1 more source