Results 241 to 250 of about 4,753,986 (376)

Role of PRKCZ non-synonymous genetic variants in breast cancer development. [PDF]

Cancer Cell Int
Mustafa A, Armaghan M, Shabbir M, Badshah Y, Khan K, Meraj L, Trembley JH, Afsar T, Almajwal A, Razak S.   +9 more
europepmc   +1 more source

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

, 2008
Robert Graham, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J. Lessard, Joanlise M Leon, Noël P. Burtt, Candace Guiducci, Melissa Parkin, Casey Gates, Robert M. Plenge, Timothy W. Behrens, Joan Wither, John D. Rioux, Paul R. Fortin, Deborah Cunninghame Graham, Andrew Wong, Timothy J. Vyse, Mark J. Daly, David Altshuler, Kathy L. Moser, Patrick M. Gaffney   +21 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Genetic variants underlying precancerous conditions of hepatocellular carcinoma. [PDF]

Int J Cancer
Guerrero JJG, Encarnacion PC, Del Rosario MAS, Ora MAS, Zhou J, Notarte KI, Li WC, Chang CW.   +7 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Spectrum of genetic variants detected in children tested for long QT syndrome. [PDF]

BMC Cardiovasc Disord
Kemezyte A, Meskiene R, Utkus A, Burnyte B.   +3 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease. [PDF]

Acta Neurol Belg
Nguyen HD.
europepmc   +1 more source

DANN: a deep learning approach for annotating the pathogenicity of genetic variants

Bioinform., 2015
Daniel Quang, Yifei Chen, Xiaohui Xie
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source