Results 241 to 250 of about 1,262,664 (328)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Role of PRKCZ non-synonymous genetic variants in breast cancer development. [PDF]

Cancer Cell Int
Mustafa A, Armaghan M, Shabbir M, Badshah Y, Khan K, Meraj L, Trembley JH, Afsar T, Almajwal A, Razak S.   +9 more
europepmc   +1 more source

Impact of Genetic Variants Associated with Neurodevelopmental Disorders on the WAVE Regulatory Complex

Song Xie, Ke Zuo, Silvia De Rubeis, Giorgio Bonollo, Giorgio Colombo, Paolo Ruggerone, Paolo Carloni   +6 more
openalex   +1 more source

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations

, 2015
Jasmine A. Luzum, Elizabeth Theusch, Kent D. Taylor, Ann Wang, Wolfgang Sadée, Philip F. Binkley, Ronald M. Krauss, Marisa W. Medina, Joseph P. Kitzmiller   +8 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. [PDF]

Nature
Demontis D, Duan J, Hsu YH, Pintacuda G, Grove J, Nielsen TT, Thirstrup J, Martorana M, Botts T, Satterstrom FK, Bybjerg-Grauholm J, Tsai JHY, Glerup S, Hoogman M, Buitelaar J, Klein M, Ziegler GC, Jacob C, Grimm O, Bayas M, Kobayashi NF, Kittel-Schneider S, Lesch KP, Franke B, Reif A, Agerbo E, Werge T, Nordentoft M, Mors O, Mortensen PB, Lage K, Daly MJ, Neale BM, Børglum AD.   +33 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Spectrum of genetic variants detected in children tested for long QT syndrome. [PDF]

BMC Cardiovasc Disord
Kemezyte A, Meskiene R, Utkus A, Burnyte B.   +3 more
europepmc   +1 more source