Results 251 to 260 of about 4,753,986 (376)

Association Between Genetic Variants in <i>DEFB1</i> Gene and Dental Caries Susceptibility. [PDF]

Int J Dent
Mokhtari MJ, Koohpeima F, Hashemi-Gorji F, Mirfakhraie R, Yassaee VR, Marjani M, Varahram M, Rezaei-Tavirani M, Omidifar N, Rezaei M.   +9 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia. [PDF]

Blood Adv
Cabrera-Serrano AJ, Sánchez-Maldonado JM, Rodríguez-Sevilla JJ, Reyes-Zurita FJ, Collado R, Puiggros A, Cornejo-Calvo E, García-Martín P, Ter Horst R, Benavente Y, Jerez A, Landi S, Espinet B, Maffei R, López-Nevot MÁ, Ramos-Campoy S, González-Olmedo C, Chen-Liang TH, Moreno V, Jannus F, Marcos-Gragera R, Carretero-Fernández M, Sampaio-Marques B, Gámez I, García-Álvarez M, Camp NJ, Dierssen-Sotos T, Kamaso J, Pérez EM, Norman AD, Luppi M, Li Y, Alcoceba M, Campa D, de San José S, Marasca R, Ludovico P, Clay-Gilmour A, Canzian F, Ibañez M, Netea MG, McKay J, Casabonne D, Berndt SI, Slager SL, Sainz J.   +45 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Genetic Variants in DVL3 are Associated With Root Maldevelopment, Tooth Agenesis, Mesiodens, and Oral Exostoses. [PDF]

Int Dent J
Kantaputra P, Bunpiem N, Guven Y, Tripuwabhrut K, Kalayci T, Imren E, Sengtae N, Pianmee C, Pruksametanan A, Tongsima S, Ngamphiw C, Kawasaki K, Ohazama A, Cairns JRK.   +13 more
europepmc   +1 more source

Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease

, 2013
Fareeha Zulfiqar, Iztok Hozo, Sneha Rangarajan, Roy A. Mariuzza, Roman Dziarski, Dipika Gupta   +5 more
openalex   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Genetic variants in HELB contribute to premature ovarian insufficiency and early age of natural menopause. [PDF]

JCI Insight
Pan Y, Yu Y, Mo J, Ren S, Zhou Z, Yang X, Liu Y, Zhang F, You Y, Zhang X, Wu Y.   +10 more
europepmc   +1 more source

The association of seminal plasma antioxidant levels and sperm chromatin status with genetic variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) in infertile men with oligoasthenoteratozoospermia.

, 2013
Niknam Lakpour, Azadeh Mirfeizollahi, Shirin Farivar, Mohammad Mehdi Akhondi, S. Behnam Hashemi, Naser Amirjannati, Hamed Heidari‐Vala, Mohammad Reza Sadeghi   +7 more
openalex   +2 more sources

Genetic variants in mRNA untranslated regions

Wiley Interdisciplinary Reviews - RNA, 2018
M. Steri, M. Idda, M. Whalen, V. Orrù
semanticscholar   +1 more source