Results 271 to 280 of about 4,570,575 (370)

Genetic Variants of Platelet Glycoprotein Receptors and Risk of Stroke in Young Women [PDF]

, 2000
Alexander P. Reiner, Prasanna N. Kumar, Stephen M. Schwartz, W.T. Longstreth, Rachel M. Pearce, Frits R. Rosendaal, Bruce M. Psaty, David S. Siscovick   +7 more
openalex   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Enhancer RNA transcription pinpoints functional genetic variants linked to asthma. [PDF]

Nat Commun
Sasse SK, Dahlin A, Sanford L, Gruca MA, Gupta A, Gally F, Wu AC, Iribarren C, Dowell RD, Weiss ST, Gerber AN.   +10 more
europepmc   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity? [PDF]

Front Cardiovasc Med
Prendergast A, Sheppard MB, Famulski JK, Nicoli S, Mukherjee S, Sips P, Elefteriades JA.   +6 more
europepmc   +1 more source

Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth (6b), seventh (7c, 7d) and ninth (9b, 9c) major genetic groups

, 1995
Hajime Tokita, Hiroaki Okamoto, Pairoj Luengrojanakul, Kriengsak Vareesangthip, T Chainuvati, H. Iizuka, Fumio Tsuda, Y. Miyakawa, M Mayumi   +8 more
openalex   +1 more source

Interpreting Genetic Variants in Titin in Patients With Muscle Disorders

JAMA Neurology, 2018
M. Savarese, L. Maggi, A. Vihola, P. Jonson, G. Tasca, L. Ruggiero, L. Bello, F. Magri, T. Giugliano, A. Torella, A. Evilä, G. Di Fruscio, O. Vanakker, S. Gibertini, L. Vercelli, A. Ruggieri, C. Antozzi, H. Luque, S. Janssens, M. Pasanisi, C. Fiorillo, M. Raimondi, M. Ergoli, L. Politano, C. Bruno, A. Rubegni, M. Pane, F. Santorelli, C. Minetti, C. Angelini, J. D. De Bleecker, M. Moggio, T. Mongini, G. Comi, L. Santoro, E. Mercuri, E. Pegoraro, M. Mora, P. Hackman, B. Udd, V. Nigro   +40 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

High-throughput screening of human genetic variants by pooled prime editing. [PDF]

Cell Genom
Herger M, Kajba CM, Buckley M, Cunha A, Strom M, Findlay GM.   +5 more
europepmc   +1 more source

The BRCA2 genetic variant IVS7 + 2T → G is a mutation [PDF]

, 2000
Michael T. Pyne, Arthur R. Brothman, Benjamin D. Ward, Dmitry Pruss, Brant C. Hendrickson, Tom Scholl   +5 more
openalex   +1 more source