Results 281 to 290 of about 4,753,986 (376)

Accelerate the discovery of genetic variants in mitochondrial diseases with Variant prIOritization using Latent spAce. [PDF]

Brief Bioinform
Labory J, Boulaimen Y, Singh J, Ait-El-Mkadem Saadi S, Paquis-Flucklinger V, Bannwarth S, Bottini S.   +6 more
europepmc   +1 more source

Chemotherapy-Related Cardiac Dysfunction: A Systematic Review of Genetic Variants Modulating Individual Risk

Circulation Genomic and Precision Medicine, 2018
M. Linschoten, A. Teske, M. Cramer, E. van der Wall, F. Asselbergs   +4 more
semanticscholar   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Genetic variants reshape the m⁶A epitranscriptome and drive transcriptomic reprogramming in colorectal cancer. [PDF]

Sci Rep
Han SH, Jang S, Kim Y, Tan K, Wilkinson MF, Jeong H, Choe J.   +6 more
europepmc   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Overview of genetic variants in a cohort of Iranian patients with leukodystrophy. [PDF]

Sci Rep
Fathi M, Khalilian S, Miryounesi M, Ghafouri-Fard S.   +3 more
europepmc   +1 more source

Correction: Genome-wide association study identifies genetic variants underlying footrot in Portuguese Merino sheep [PDF]

Daniel Gaspar, Catarina Ginja, N. Carolino, Célia Leão, Helena Monteiro, Lino Tábuas, Sandra Branco, Ludovina Padre, Pedro Caetano, Ricardo Romão, Claudino Matos, António Marcos Ramos, Elisa Bettencourt, Ana Usié   +13 more
openalex   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Genetic variants associated with ventricular arrhythmias during ajmaline test in Brugada syndrome. [PDF]

Europace
Audiat C, Pannone L, Sorgente A, Vergara P, Della Rocca DG, Eltsov I, Pappaert G, Overeinder I, Bala G, Almorad A, Ströker E, La Meir M, Gharaviri A, De Schutter E, Vlaeminck J, Helsen C, Uyttebroeck S, Van Dooren S, Pölsler L, Giron P, Brugada P, Sarkozy A, Chierchia GB, Sieira J, de Asmundis C.   +24 more
europepmc   +1 more source